Inventors:
Michelle M. Wiest - Knights Landing CA, US
Steven M. Watkins - Sacramento CA, US
Rebecca Ann Baillie - Woodland CA, US
Madhumita Patnaik - Agoura Hills CA, US
K. Ranga Rama Krishnan - Chapel Hill NC, US
Richard M. Weinshilboum - Rochester MN, US
Ronald M. Krauss - Berkeley CA, US
Assignee:
Children's Hospital & Research Center at Oakland - Oakland CA
Duke University - Durham NC
Lipomics Technologies, Inc. - West Sacramento CA
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
G01N 33/92
C12Q 1/60
Abstract:
The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.