Richard L Tidwell

6486200, Nov 26, 2002

Jul 7, 2000

09/612138

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 31357

514467, 514473, 549448, 549450, 549451

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NRâ wherein Râ is H or loweralkyl; R and R may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R and R are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R is represented by a formula selected from the group consisting of: âwherein: X , X , and X are independently selected from O and S; and R and R are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.

6503940, Jan 7, 2003

Jul 31, 2001

09/918787

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 3140

514422, 548541, 548556, 549448, 549449, 549450, 549451, 514423

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NRâ wherein Râ is H or loweralkyl, R and R may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R and R are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R is represented by a formula selected from the group consisting of: wherein: X , X , and X are independently selected from O and S; and R and R are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.

6613787, Sep 2, 2003

Dec 20, 2000

09/745004

W. David Wilson - Atlanta GA
David W. Boykin - Atlanta GA
Richard R. Tidwell - Pittsboro NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 31415

514394, 5483047, 549472

Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.

6649652, Nov 18, 2003

Jul 30, 2002

10/208947

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

C07D31704

514467, 514473, 549229, 549448, 549449, 549451

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I).

6737440, May 18, 2004

Nov 6, 2001

10/008535

David W. Boykin - Atlanta GA
Richard R. Tidwell - Pittsboro NC
W. David Wilson - Atlanta GA
John R. Perfect - Durham NC
Chad F. Stephens - Villa Rica GA

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA
Duke University - Durham NC

A61K 3127

514491, 514472, 549491, 549472

The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R , R , R and R are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R is H, alkyl or aryl; R is H, alkyl, aryl, or NR R , in which R and R are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR , in which R is H or alkyl, and to the use of such compounds.

6867227, Mar 15, 2005

Sep 2, 2003

10/653677

W. David Wilson - Atlanta GA, US
David W. Boykin - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K031/423
A61K031/4184
C07D235/15
C07D263/57
C07D413/04

514375, 514394, 548224, 5483047

Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.

7071338, Jul 4, 2006

Nov 25, 2003

10/722085

David W. Boykin - Altanta GA, US
Mariappan Anbazhagan - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

C07D 207/335
C07D 307/52
C07D 333/22

548561, 549 74, 549491

Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl]furans, are useful as therapeutic compounds. The disclosed process is scalable, simpler, more economic and more feasible than other presently known methods of preparing 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl]furans and other bis-aryl diamidoxime compounds.

7160914, Jan 9, 2007

Jan 14, 2005

11/035627

W. David Wilson - Atlanta GA, US
David W. Boykin - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 31/4184
A61K 31/4164
C07D 403/04
C12Q 1/04
C12Q 1/24

514393, 5483061, 435 6

Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.