Richard Alan Edrich

8296071, Oct 23, 2012

Mar 14, 2005

11/079894

Richard Alan Edrich - Denver CO, US
Laura Goodrich - Lakewood CO, US
Glen Delbert Antwiler - Lakewood CO, US

Terumo BCT Biotechnologies, LLC - Lakewood CO

G01N 33/48

702 19

Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate on the basis of the volume, mass or mixing rate of the fluid or any combination of these variables. In another aspect, the present invention provides algorithms for determining net radiation energies, radiant powers, and/or illumination times necessary for providing uniform treatment of fluid samples. The present invention provides methods for uniformly reducing pathogens in biological fluids, including blood and blood components.

20030228564, Dec 11, 2003

Feb 10, 2003

10/364661

Richard Edrich - Denver CO, US
Laura Goodrich - Lakewood CO, US
Reinhold Deppisch - Hechingen, DE
Dennis Hlavinka - Arvada, CO
Robert Lockerbie - Littleton CO, US
Werner Beck - Rottenburg, DE

A01N001/02
A61K031/7076
A61K031/198
A61K033/00

435/002000, 424/718000, 514/047000, 514/048000, 514/562000, 514/565000

This invention provides methods and compositions for using nitric oxide in a photoradiation pathogen inactivation process for whole blood and blood components to improve pathogen kill and to improve preservation of the quality of the blood components. This invention provides methods for using nitric oxide in combination with oxygen, photosensitizers, quencher and/or glycolysis inhibitor, and compositions comprising blood components decontaminated by these methods. Nitric oxide is provided using nitric oxide gas, or nitric oxide generators such as L-arginine, and/or N-acetyl-cysteine. This invention also provides compositions suitable for photoradiation pathogen inactivation that include fluid comprising a blood component, a photosensitizer, and dissolved nitric oxide. This invention provides decontamination systems useful for performing the methods of this invention and methods for making the decontamination systems. This invention also provides methods for decontaminating fluids and methods for increasing the storage life and quality of photochemically decontaminated platelets.

20110136646, Jun 9, 2011

Nov 9, 2010

12/942430

Thomas PEARCE - Littleton CO, US
Hong Duc NGUYEN - Lafayette CO, US
Bruce ELLINGBOE - Littleton CO, US
Richard Alan EDRICH - Denver CO, US

CARIDIANBCT, Inc. - Lakewood CO

B04B 11/00
B65D 30/00

494 5, 383 37

An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising an asymmetrical junction or manifold in the blood bag and tubing set inhibits errors when the bags and tubes are loaded into the device.

20110136650, Jun 9, 2011

Nov 10, 2010

12/943650

Bruce ELLINGBOE - Littleton CO, US
Richard Alan EDRICH - Denver CO, US
Thomas PEARCE - Littleton CO, US

CARIDIANBCT, INC. - Lakewood CO

B04B 1/04

494 76

An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a well provided on a rotor near the axis of rotation for receiving a relatively rare blood component, such as mesenchymal stem cells (MSC), or for receiving a fluid that can be used multiple times, such as a washing solution. The well is placed radially outwardly from the axis of rotation and radially inwardly from cavity, which receives bags containing blood or another biologic fluid. The well is placed in a low centrifugal force region relative to the position of the cavity.

20140016883, Jan 16, 2014

Jul 5, 2013

13/935843

Victor D. DOLECEK - Englewood CO, US
Richard Alan EDRICH - Denver CO, US

A61M 1/02

383109, 156 60

A hybrid blood component storage bag having one side of the bag with a greater permeability than another side of the bag and the method of making such bag.

57028230, Dec 30, 1997

Oct 10, 1996

8/728823

Lloyd Forrestal - Boulder CO
Marc Voorhees - Arvada CO
Yung-Ming Chen - Westminster CO
Richard A. Edrich - Denver CO

COBE Laboratories, Inc. - Lakewood CO

B32B 1508

458450

The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.