Search

Richard A Blatchly

from Amherst, MA
Age ~69

Richard Blatchly Phones & Addresses

  • 327 Shutesbury Rd, Amherst, MA 01002 (413) 256-1963
  • Moravia, NY
  • Shelburne Falls, MA
  • Groton, NY
  • 327 Shutesbury Rd, Amherst, MA 01002 (413) 329-8083

Work

Position: Transportation and Material Moving Occupations

Education

Degree: Associate degree or higher

Emails

Publications

Us Patents

Gar Transformylase Inhibitor

View page
US Patent:
49994247, Mar 12, 1991
Filed:
Nov 10, 1988
Appl. No.:
7/269510
Inventors:
Stephen J. Benkovic - State College PA
Richard A. Blatchly - Shelburne Falls MA
James Inglese - E. Hanover NJ
Assignee:
The Pennsylvania State University - State College PA
International Classification:
C07H 906
A61K 3170
A61K 31395
US Classification:
536 22
Abstract:
The present invention is directed to several multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase (GAR TFase; E. C. 2. 1. 2. 2), a folate-requiring enzyme of de novo purine biosynthesis. The compounds of the present invention will be useful to provide anti-gout and/or anti-neoplastic therapeutic agents or will serve as potentiators for other such agents. The most prefeffed, potent tight-binding multisubstrate adduct inhibitor of glycinamide ribonucleotide transformylase, is N. sup. 10 -[5'-phosphoribosyl-1'-. beta. -aminocarbonylmethyl-1-thioacetyl]-5,8-dideaz afolate, which has the chemical formula: ##STR1##.
Richard A Blatchly from Amherst, MA, age ~69 Get Report