Reinier Beeuwkes

54133815, May 9, 1995

Jun 14, 1993

8/075379

Reinier Beeuwkes - Concord MA
Thomas E. Salisbury - Wayland MA
Robert C. Gorin - Newton Centre MA

Innoves, Inc. - Concord MA

B42D 110
B42C 900

281 211

An adhesive bound pad of paper such as loose leaf binder paper is provided which is secured in assembly by adhesive material, lining or partially lining holes along selected edges of the paper stack forming the pad. The edges of the paper pad remain free of adhesive material and thus are not distorted upon separation of the sheets from the pad. The adhesive bound pad is manufactured by assembling a selected number of sheets of paper into a stack and drilling or otherwise forming holes, such as binder holes, along one of the edges of the stack. Thereafter, the coating of adhesive material is applied within the holes of the stack so as to entirely coat the paper at the holes or to coat selected portions of the paper at the holes as desired. After the adhesive material has been allowed to cure or has been cured the paper is releasably retained in adhesive bound pad form and the manufacturing process is complete. Individual sheets of paper may be pulled away from the pad.

53931840, Feb 28, 1995

Sep 20, 1993

8/123678

Reinier Beeuwkes - Concord MA

F16B 1500
F16B 1502

411469

A self-retaining staple construction is provided having a retainer bridge from which extend a pair of spaced, sharp pointed staple legs which are capable of penetrating a structure. The staple is provided with opposed inwardly directed retainer projections which permit assembly of the staple construction to an object and which retain the staple in assembly with the object. These retainer projections may be defined by resilient or rigid retainer members and may include an adhesive composition for securing the staple to an object.

58462120, Dec 8, 1998

Mar 28, 1996

8/623921

Reinier Beeuwkes - Concord MA
Harold E. Clupper - West Chester PA

Therabite Corporation - Newton Square PA

A63B 2303

601 38

A translator apparatus for achieving omnidirectional translation of the mandible of a human patient and having a maxillary translation plate having a maxillary mouthpiece thereon for temporarily fixing the maxillary dentition of a patient thereto. A mandibular translation plate is provided, also having a mandibular mouthpiece for temporary fixation with the mandibular dentition of the patient and the mandibular element. A translation control plate is interposed between the maxillary and mandibular translation plates and establishes linearly moveable guiding relation with elongate guide slots of both the maxillary and mandibular plates. The guide slots of the respective translation plates which may be straight or of curved configuration are arranged in 90 degree relation to permit relative omnidirectional translatory positioning and movement of the translation plates for consequent selective omnidirectional therapeutic or diagnostic positioning or movement of the mandible of a patient. A translation actuator is supported by one of the translation plates and has mechanical interaction with the maxillary and mandibular translation plates and is operative to establish protrusive, retrusive and lateral movement of the mandibular plate and mouthpiece for corresponding omnidirectional protrusive, retrusive and lateral therapeutic movement of the mandible of the patient or for diagnostic positioning and movement of the mandible.

53615069, Nov 8, 1994

May 26, 1993

8/067748

Reinier Beeuwkes - Concord MA

Therabite Corporation - Newtown Square PA

A61B 5103
A61C 1904
G01B 314
G01B 514

33512

A measurement device is provided for measuring the degree of mandibular movement during therapy following maxillofacial surgery or to otherwise accomplish measurement of jaw movement. The measurement device is in the form of a flat object having a rounded end and defining a reference depression for receiving the incisal edge of the teeth of either the mandibular or maxillary arches. The measurement device includes a curved end and a slightly curved top which are provided with indicia to indicate the degree of jaw opening by comparing the location of an incisal edge with respect to the indicia. The measurement device along a straight end is provided with measurement indicia to enable effective measurement of lateral jaw movement and to accomplish measurement of movement relative to the occlusal plane of the patient's dentition.

54567033, Oct 10, 1995

Aug 10, 1994

8/288437

Reinier Beeuwkes - Concord MA

Therabite Corporation - Newtown Square PA

A61F 700

607109

Apparatus is provided for applying heat/cold to selected target regions of the human anatomy such as the temporalis and masseter muscles and to the region of the temporo-mandibular joint of the human cranial anatomy as well as other selected regions of the human anatomy such as the shoulders, knees, etc. At least one heat/cold compliant thermal cell is defined by a rigid back having a thin and compliant membrane connected thereto and defining a chamber for containing a substantial volume of a liquid or semi-liquid such as water or a gel, at a preselected temperature. The rigid back or shell defines a circumferential rim to which the compliant membrane is secured. The compliant membrane may have a side wall portion extending in substantially contiguous relation from the rim of the rigid shell and incorporates an integral substantially planar front wall portion which establishes intimate face-to-face heat/cold transferring relation with an anatomical target region. The membrane will engage the target region with low pressure per unit area and thus will readily conform to the configuration of the target region. The rigid shell defines a liquid inlet/outlet opening which is provided with a removable closure enabling heated or cooled liquid to be poured into or from the internal compartment.

20220280477, Sep 8, 2022

Dec 15, 2021

17/644459

- Grafton MA, US
Reinier Beeuwkes - Concord MA, US
Ralph Casale - Westford MA, US
Steven A. Kates - Needham MA, US
Alan S. Lader - Stoughton MA, US

A61K 31/385
A61P 25/28
A61K 31/662
A61K 45/06
A61K 31/661
A61K 31/4178

The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury (TBI) using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.

20200352904, Nov 12, 2020

Jul 30, 2020

16/943088

- North Grafton MA, US
Reinier Beeuwkes - Concord MA, US
Ralph Casale - Westford MA, US
Steven A. Kates - Needham MA, US
Alan S. Lader - Stoughton MA, US

A61K 31/385
A61P 25/28
A61K 31/662
A61K 45/06
A61K 31/661
A61K 31/4178

The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.

20180303796, Oct 25, 2018

Apr 25, 2018

15/962575

- North Grafton MA, US
Reinier Beeuwkes - Concord MA, US
Ralph Casale - Westford MA, US
Steven A. Kates - Needham MA, US
Alan S. Lader - Stoughton MA, US

A61K 31/385
A61P 25/28

The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.