Inventors:
Raoul Kopelman - Ann Arbor MI
Heather Clark - Middletown CT
Susan Barker - Silver Spring MD
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
G02B 600
US Classification:
385 12, 385 38, 385127, 385128
Abstract:
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity. Additionally, metals functionally linked to reporter dyes are described in addition to the incorporation of reference compounds for ratiometric measurements.