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Raoul Chava Kopelman

from Ann Arbor, MI
Age ~91
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Also known as:
Raoul M Kopelman, Raoul C Kopelman, Raoul X Kopelman, Chava B Kopelman, Kopelman Raoul
Phone and address:
1065 Heather Way, Ann Arbor, MI 48104
(734) 973-2210
Related to:
Sheryl L Kelley, 64Lawrence GallKhadijah Gigliotti, 67Pedro VazquezlopezJoan Gall
Connected to:
Alexander Kopelman, 63Larry G Kopelman, 75Lawrence M Kopelman, 71Michal Kopelman, 61Selma P Kopelman, 91Susan S Kopelman, 54Alexander Kopelowitz, 45Merry G Kopelove, 71Tomer Kopelovich, 64Catherine L Kopels, 42

Raoul Kopelman Phones & Addresses

  • 1065 Heather Way, Ann Arbor, MI 48104 (734) 973-2210 (734) 971-6634 (734) 971-6693
  • Livonia, MI
  • Palo Alto, CA

Publications

Us Patents

Optical Fiberless Sensors

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US Patent:
6379955, Apr 30, 2002
Filed:
Sep 20, 2000
Appl. No.:
09/665789
Inventors:
Raoul Kopelman - Ann Arbor MI
Heather Clark - Middletown CT
Eric Monson - Ann Arbor MI
Stephen Parus - Ann Arbor MI
Martin Philbert - Ann Arbor MI
Bjorn Thorsrud - Lima OH
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
C12N 500
US Classification:
435325, 435 4, 435 29, 435164, 435172, 435805, 422 8205, 422 8706
Abstract:
Fiberless optical sensors (plasticized PVC, acrylamide or gold particles) are described having a size ranging from between approximately 1 micrometer and 1 nanometer in diameter. The sensors comprise ionophores useful for the detection of intracellular analytes.

Optical Sensors For The Detection Of Nitric Oxide

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US Patent:
6636652, Oct 21, 2003
Filed:
Aug 2, 1999
Appl. No.:
09/365487
Inventors:
Raoul Kopelman - Ann Arbor MI
Heather Clark - Middletown CT
Susan Barker - Silver Spring MD
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
G02B 600
US Classification:
385 12, 385 38, 385127, 385128
Abstract:
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity. Additionally, metals functionally linked to reporter dyes are described in addition to the incorporation of reference compounds for ratiometric measurements.

Optical Sensors For The Detection Of Nitric Oxide

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US Patent:
6900891, May 31, 2005
Filed:
Jul 30, 2003
Appl. No.:
10/630928
Inventors:
Raoul Kopelman - Ann Arbor MI, US
Heather Clark - Middletown CT, US
Susan Barker - Charlottesville VA, US
Assignee:
The Regents of the University of Michigan - Ann Harbor MI
International Classification:
G01N021/64
US Classification:
356318, 2504581, 436172
Abstract:
Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.

Photoacoustic Indicators

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US Patent:
7576334, Aug 18, 2009
Filed:
Mar 18, 2008
Appl. No.:
12/050493
Inventors:
Shai Ashkenazi - Ann Arbor MI, US
Raoul Kopelman - Ann Arbor MI, US
Russell S. Witte - Tucson AZ, US
Thomas D. Horvath - Little Rock AR, US
Gwangseong Kim - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
G01N 21/64
US Classification:
2504591, 2504581
Abstract:
A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.

Universal, Wireless, Nano-Optical Voltmeters

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US Patent:
7923984, Apr 12, 2011
Filed:
Jan 17, 2008
Appl. No.:
12/015674
Inventors:
Martin A. Philbert - Northville MI, US
Katherine M. Tyner - Silver Spring MD, US
Raoul Kopelman - Ann Arbor MI, US
Assignee:
The Regents of the University Of Michigan - Ann Arbor MI
International Classification:
G01R 19/02
US Classification:
324 96, 977788
Abstract:
A universal, wireless, nano-optical voltmeter comprises an organic core having at least one voltage-sensitive dye and at least one polymeric shell substantially surrounding the organic core. The nano-optical voltmeter can detect electric fields in cells. The nano-optical voltmeter allows three-dimensional E field profiling throughout the entire volume of living cells. The nano-optical voltmeter may be calibrated externally and then applied for E field determinations inside any live cell or cellular compartment, with no further calibration steps.

Paa Nanoparticles For Enhancement Of Tumor Imaging

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US Patent:
8562944, Oct 22, 2013
Filed:
Oct 21, 2010
Appl. No.:
12/909573
Inventors:
Ravindra K. Pandey - Williamsville NY, US
Raoul Kopelman - Ann Arbor MI, US
Anurag Gupta - Hamburg NY, US
Munawwar Sajjad - Clarence Center NY, US
Assignee:
Health Research, Inc. - Buffalo NY
The Research Foundation of State University of NY - Amherst NY
Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 51/00
A61K 49/06
A61K 49/00
C07D 487/22
B82Y 5/00
US Classification:
424 111, 424 93, 424 961, 424 91, 977930, 977773, 977927, 540145
Abstract:
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.

Optical Fiberless Sensors

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US Patent:
20020155600, Oct 24, 2002
Filed:
Apr 30, 2002
Appl. No.:
10/135168
Inventors:
Raoul Kopelman - Ann Arbor MI, US
Heather Clark - Middletown CT, US
Eric Monson - Ann Arbor MI, US
Stephen Parus - Ann Arbor MI, US
Martin Philbert - Ann Arbor MI, US
Bjorn Thorsrud - Lima OH, US
International Classification:
C12N005/00
C12N005/02
US Classification:
435/325000
Abstract:
Fiberless optical sensors (plasticized PVC, acrylamide or gold particles) are described having a size ranging from between approximately 1 micrometer and 1 nanometer in diameter. The sensors comprise ionophores useful for the detection of intracellular analytes.

Modulated Chemical Sensors

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US Patent:
20040058458, Mar 25, 2004
Filed:
Apr 18, 2003
Appl. No.:
10/419033
Inventors:
Jeffrey Anker - Ann Arbor MI, US
Eric Monson - Durham NC, US
Raoul Kopelman - Ann Arbor MI, US
Martin Philbert - Plymouth MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
G01N033/553
US Classification:
436/526000
Abstract:
The present invention relates to modulated (e.g., magnetically modulated) chemical sensors. In particular, the present invention relates to particles comprising fluorescent indicator dyes and methods of using such particles. Magnetic fields and/or Brownian motion modulate an optical property of the particle to distinguish it from background signals. The present invention thus provides improved methods of detecting a wide variety of analytes in fluids, fluid samples, cells and tissues.
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Raoul Chava Kopelman from Ann Arbor, MI, age ~91 Get Report