Randel E Dorian

6905612, Jun 14, 2005

Mar 21, 2003

10/394828

Randel Dorian - San Diego CA, US
Richard Wood Storrs - San Francisco CA, US

Hanuman LLC - San Francisco CA

B01D037/00
B01D015/02
B01D024/00
B01D029/00

210806, 210219, 2102571, 2104161, 2105021, 210649, 210689, 422 44, 422102, 435 2, 436177, 436178

A plasma concentrator for producing plasma concentrate from a plasma from which erythrocytes have been substantially removed. The device comprises a concentrating chamber having an inlet port and an concentrate outlet, the concentrating chamber containing hydrogel beads and at least one inert agitator; and a concentrate chamber having an inlet communicating with the concentrator outlet through a filter, and having an plasma concentrate outlet port. A process for producing plasma concentrate from plasma from which erythrocytes have been substantially removed, comprising the steps of a) moving the plasma into a concentrating chamber containing hydrogel beads and an agitator to form a hydrogel bead-plasma mixture; b) causing the agitator to stir the hydrogel bead-plasma mixture, facilitating absorption of water by the beads from the plasma, until a hydrogel bead-plasma concentrate is formed; and c) separating the plasma concentrate from the hydrogel beads by passing the plasma concentrate through a filter. The concentrator can be one or more syringe devices coupled for multiple concentrations.

7223346, May 29, 2007

Apr 18, 2005

11/108387

Randel Dorian - San Diego CA, US
Scott R. King - San Francisco CA, US
Richard Wood Storrs - San Francisco CA, US

Hanuman LLC - San Francisco CA

B01D 21/26
B01D 45/12
B01L 11/00
B04B 5/02
B04B 7/12
B04B 7/00

210787, 210109, 210121, 2105121, 210518, 210789, 422101, 494 16, 494 37, 494 45, 494 48, 494 56

A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

7470371, Dec 30, 2008

Oct 19, 2006

11/584414

Randel Dorian - San Diego CA, US
Scott R. King - San Francisco CA, US
Richard Wood Storrs - San Francisco CA, US

Hanuman LLC - San Francisco CA

C02F 1/38
B04B 1/04
B04B 1/06
B04B 3/02
B04B 1/00

210787, 210109, 210121, 2105121, 210516, 210518, 210361, 210789, 422102, 422918, 436177, 494 16, 494 37, 494 38, 494 45, 494 56

A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

7553413, Jun 30, 2009

Jan 30, 2006

11/342982

Randel Dorian - San Diego CA, US
Michael D. Leach - Warsaw IN, US
Richard Wood Storrs - Berkeley CA, US

Hanuman LLC - San Francisco CA
Biomet Biologics, LLC - Warsaw IN

B01D 15/02
B01D 24/00
B01D 29/00

210219, 210295, 2105021, 422 44, 422102, 436177, 436178

A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma.

7708152, May 4, 2010

Jan 30, 2006

11/342761

Randel Dorian - San Diego CA, US
Michael D. Leach - Warsaw IN, US

Hanuman LLC - San Francisco CA
Biomet Biologics, LLC - Warsaw IN

B01D 21/26
B04B 7/08

2105123, 210319, 210294, 21032168, 21032187, 2103801, 210787, 2103601, 2105121, 494 35, 494 37

The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

7806276, Oct 5, 2010

Apr 11, 2008

12/101594

Michael D. Leach - Warsaw IN, US
Randel Dorian - San Diego CA, US
Jacy C. Hoeppner - Warsaw IN, US

Hanuman, LLC - San Francisco CA
Biomet Biologics, LLC - Warsaw IN

B01D 21/26
B01D 17/02
B01D 17/038
C02F 1/38

210516, 2102421, 210513, 210515, 210518, 422101

A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

7824559, Nov 2, 2010

Jan 30, 2006

11/342749

Randel Dorian - San Diego CA, US
Michael D. Leach - Warsaw IN, US

Hanumann, LLC - San Francisco CA
Biomet Biologics, LLC - Warsaw IN

B01D 21/26
B01D 33/00
B01D 35/00
B01D 37/00
B04B 1/04
B04B 3/00

210782, 2103601, 210781, 210784, 210787, 210789, 210767, 494 2, 494 4, 494 36, 494 37, 494 43, 494 54, 494 67, 494 74, 494 79

A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports.

7837884, Nov 23, 2010

Dec 29, 2008

12/344895

Randel Dorian - San Diego CA, US
Scott R. King - San Francisco CA, US
Richard Wood Storrs - Berkeley CA, US

Hanuman, LLC - San Francisco CA

C02F 1/38
B04B 1/04
B04B 1/06
B04B 3/02
B04B 1/00

210787, 210109, 210121, 2105121, 210516, 210518, 210361, 210789, 422102, 422918, 436177, 494 16, 494 37, 494 38, 494 45, 494 56

A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.