Inventors:
Koteswara Rao KOLLIPARA - Hyderabad, IN
Ramesh Babu BATCHU - Royal Oak MI, US
Assignee:
TRANSGENE BIOTEK LTD. - Medak District
International Classification:
C07K 16/30
A61K 39/395
A61P 35/04
G01N 33/566
US Classification:
4241381, 436501, 530326, 5303877, 5303873
Abstract:
Antibody for targeted induction of Apoptosis, CDC and ADCC mediated killing of Cancer cells, TBL-CLN1, is disclosed. The antibodies, TBL-CLN1, are monoclonal antibodies which can specifically target and bind to the epitope of SEQ ID NO:1 expressed on cancer cells which further leads to killing of cancer cells. TBL-CLN1 is not conjugated to toxin or cytotoxic molecules, and provides selective killing of cancer cells just by binding to cancer cell surface. Also, disclosed herein is SEQ ID NO: 2 which is an engineered epitope which comprises of polypeptide sequence of SEQ ID NO: 1 and a cysteine residue which is added at the carboxyl end of the SEQ ID NO: 1. The epitope of SEQ ID NO: 2 is used to generate monoclonal antibodies described herein.