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Quinn Zhu

from Wilmington, DE
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Related to:
Jingshu Chen, 44Qiwen Chen, 37Kunchang Yu, 54Chunyang Wang, 38Dujiu M Yang, 61
Connected to:
Abby Zhu, 40Ada Zhu, 32Aileen J Zhu, 31Alyssa H Zhu, 35Ankang Zhu, 65Anwei W Zhu, 50Audrey Zhu, 27Bai C Zhu, 70Bangmin Zhu, 58Bao Y Zhu, 51

Quinn Zhu Phones & Addresses

  • Wilmington, DE

Resumes

Resumes

Quinn Zhu Photo 1

Senior Research Fellow

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Location:
Collegeville, PA
Industry:
Chemicals
Work:
DuPont
Research Fellow
DuPont - Experimental Station since Apr 1998
Dr.
DuPont Company since 1998
Research Fellow
Education:
Chinese Academy of Science 1983 - 1988
Doctorates, Doctor of Philosophy, Molecular Biology, Philosophy Nanjing Normal University 1979 - 1983
Bachelors, Bachelor of Science, Biology
Skills:
Biochemistry
Chemistry
Biotechnology
Molecular Biology
R&D
Microbiology
Life Sciences
Protein Chemistry
Technology Transfer
Genetics
Protein Purification
Purification
Genomics
Hplc
Commercialization
Lifesciences
Research and Development
High Performance Liquid Chromatography
Languages:
English
Mandarin
Quinn Zhu Photo 2

Quinn Zhu

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Publications

Us Patents

Fructose-Bisphosphate Aldolase Regulatory Sequences For Gene Expression In Oleaginous Yeast

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US Patent:
7202356, Apr 10, 2007
Filed:
Nov 12, 2004
Appl. No.:
10/987548
Inventors:
Dana M. Walters Pollak - Media PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C07H 21/04
C12Q 1/68
G01N 33/53
C12N 15/00
C12N 15/63
C12P 21/04
C12N 1/19
US Classification:
536 241, 435 6, 435 731, 435 691, 435 699, 4353201
Abstract:
The regulatory sequences (i. e. , promoter regions, introns and enhancers) associated with the gene encoding fructose bis-phospate aldolase (FBA1) have been found to be particularly effective for the expression of heterologus genes in oleaginous yeast. The promoter regions of the invention have been shown to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.

Production Of Polyunsaturated Fatty Acids In Oleaginous Yeasts

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US Patent:
7238482, Jul 3, 2007
Filed:
May 6, 2004
Appl. No.:
10/840579
Inventors:
Stephen K. Picataggio - Landenberg PA, US
Narendra S. Yadav - Chadds Ford PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C12Q 1/68
C12N 1/19
C07H 21/04
C12N 15/63
US Classification:
435 6, 435 41, 4352541, 4352542, 43525411, 43525422
Abstract:
The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to arachidonic acid (ARA); ETA to eicosapentaenoic acid (EPA); DGLA to ETA; EPA to docosapentaenoic acid (DPA); and ARA to EPA have been introduced into the genome of for synthesis of ARA and EPA.

Delta-8 Desaturase And Its Use In Making Polyunsaturated Fatty Acids

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US Patent:
7256033, Aug 14, 2007
Filed:
Jun 24, 2005
Appl. No.:
11/166993
Inventors:
Howard Glenn Damude - Hockessin DE, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C12N 1/19
C12N 1/16
C12N 9/04
C12N 15/70
C12P 11/00
C12P 21/06
C07H 21/04
US Classification:
4352523, 4352542, 4352551, 43525422, 435 691, 435134, 435190, 4353201, 536 232
Abstract:
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast.

Glyceraldehyde-3-Phosphate Dehydrogenase And Phosphoglycerate Mutase Promoters For Gene Expression In Oleaginous Yeast

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US Patent:
7259255, Aug 21, 2007
Filed:
Jun 16, 2004
Appl. No.:
10/869630
Inventors:
Stephen K. Picataggio - Landenberg PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C07H 21/04
C12N 12/81
C12N 1/00
US Classification:
536 241, 4353201, 435 691, 4352551
Abstract:
The promoter regions associated with the glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the invention have been shown to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.

Glycerol-3-Phosphate O-Acyltransferase Promoter For Gene Expression In Oleaginous Yeast

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US Patent:
7264949, Sep 4, 2007
Filed:
Sep 13, 2005
Appl. No.:
11/225354
Inventors:
Zhixiong Xue - Chadds Ford PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C12P 1/00
C12P 21/04
US Classification:
435 712, 435 41, 435 45, 435 711
Abstract:
The promoter region associated with the glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the instant invention have been shown to be suitable to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.

Codon-Optimized Genes For The Production Of Polyunsaturated Fatty Acids In Oleaginous Yeasts

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US Patent:
7335476, Feb 26, 2008
Filed:
Aug 4, 2006
Appl. No.:
11/499549
Inventors:
Stephen K. Picataggio - Landenberg PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C12Q 1/68
C12N 1/00
C07H 21/04
C12N 15/63
US Classification:
435 6, 4352542, 43525411, 536 231
Abstract:
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.

Glyceraldehyde-3-Phosphate Dehydrogenase And Phosphoglycerate Mutase Regulatory Sequences For Gene Expression In Oleaginous Yeast

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US Patent:
7459546, Dec 2, 2008
Filed:
Jul 18, 2005
Appl. No.:
11/183664
Inventors:
Stephen K. Picataggio - Landenberg PA, US
Quinn Qun Zhu - West Chester PA, US
Assignee:
E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C07H 21/04
C12N 12/81
C12N 1/00
US Classification:
536 241, 4353201, 435 691, 4352551
Abstract:
The regulatory sequences associated with the glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the invention, intron and enhancer have been shown to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.

Production Of Γ-Linolenic Acid In Oleaginous Yeast

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US Patent:
7465564, Dec 16, 2008
Filed:
Aug 8, 2005
Appl. No.:
11/198975
Inventors:
Quinn Qun Zhu - West Chester PA, US
Dana M. Walters Pollak - Media PA, US
Assignee:
E.I. du Pont de Nemours and Company - Wilmington DE
International Classification:
C12Q 1/68
C07H 21/04
C12P 21/06
US Classification:
435134, 4352542, 4352523, 435 692, 536 232
Abstract:
The present invention relates to methods for the production of γ-linolenic acid (GLA) in oleaginous yeast. Thus, Δ12 and Δ6 desaturases able to catalyze the conversion of oleic acid to GLA have been introduced into the genome of , using zeta-directed integration. Transformed strains produced over 25% GLA in the total lipids, as opposed to wildtype that is unable to synthesize any GLA. Metabolic engineering and fermentation methods are provided to further enhance GLA productivity in oleaginous yeast.
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Quinn Zhu from Wilmington, DE Get Report