Qianjin Fang Shuling Hu

6376191, Apr 23, 2002

Nov 6, 2000

09/707366

Zailin Yu - San Leandro CA
Zaoyuan Peng - Palo Alto CA
Qianjin Hu - Castro Valley CA

Mergen, Ltd. - San Leandro CA

C12Q 168

435 6, 435 912, 536 2433

Solid phase polymerase-mediated amplification approaches using immobilized primers on a microarray are provided for detecting sequence variations in a target polynucleotide. The methods and compositions provided herein are useful for research and clinical applications, particularly for large scale assays of genetic information in biological samples of interest.

6500620, Dec 31, 2002

Dec 19, 2000

09/741983

Zailin Yu - San Leandro CA
Zaoyuan Peng - Palo Alto CA
Qianjin Hu - Castro Valley CA

Mergen Ltd. - San Leandro CA

C12Q 168

435 6, 435 911, 435 912, 536 2433

Methods for solid phase polymerase-mediated amplification using immobilized primers on a microarray are provided for detecting and cloning multiple target polynucleotides. The methods, compositions and kits provided herein are useful for research and clinical applications, particularly for large scale assays of genetic information in biological samples of interest.

20020048823, Apr 25, 2002

Aug 13, 2001

09/929874

Qianjin Hu - Castro Valley CA, US

G01N033/543

436/518000

The invention provides compositions, methods and systems that comprise or use an array of a library of monoclonal antibodies for identifying a monoclonal antibody specific for a target antigen; or for profiling a plurality of unknown antigens from a particular source such as cells, cell lysates, tissues, or animals by the antigens' monoclonal antibody binding characteristics. The invention is useful to find a monoclonal antibody for an antigen, or to characterize antigen from a particular source (e.g. a source comprising an animal having a disease) in order to develop tools for understanding a condition (e.g. the disease) in that source.

20020076761, Jun 20, 2002

Aug 22, 2001

09/935390

Jaime Escobedo - Alamo CA, US
Pablo Garcia - San Francisco CA, US
Qianjin Hu - Castro Valley CA, US
Srinivas Kothakota - Santa Monica CA, US
Lewis Williams - Mill Valley CA, US

C12Q001/68
C07H021/04
C12N009/00
C12P021/02
C12N005/06
C07K014/435

435/069100, 435/183000, 435/320100, 435/325000, 435/006000, 530/350000, 536/023500

Secreted proteins can be identified using a method which exploits the ability of microsomes to modify proteins post-translationally. Nineteen human secreted proteins and full-length cDNA sequences encoding the proteins have been identified using this method. The proteins and cDNA sequences can be used, inter alia, for targeting other proteins to the membrane or extracellular milieu.

20020086322, Jul 4, 2002

Dec 5, 2001

10/008560

Zailin Yu - San Leandro CA, US
Zaoyuan Peng - Palo Alto CA, US
Qianjin Hu - Castro Valley CA, US

C12Q001/68
C07H021/04
C12P019/34
C12M001/34

435/006000, 435/091200, 536/024300, 435/287200

Solid phase polymerase-mediated amplification approaches using immobilized primers on a microarray are provided for detecting sequence variations in a target polynucleotide. The methods and compositions provided herein are useful for research and clinical applications, particularly for large scale assays of genetic information in biological samples of interest.

20020155473, Oct 24, 2002

Dec 21, 2001

10/032106

Zaoyuan Peng - Palo Alto CA, US
Zailin Yu - San Leandro CA, US
Andrew Wiley - Napa CA, US
Qianjin Hu - Castro Valley CA, US

C12Q001/68

435/006000

The present invention describes a method for isolating novel G-protein coupled receptors (GPCRs) whose expression is associated with disease states. The invention provides polynucleotide and polypeptide sequences whose expression is associated with neurodegenerative diseases and cancer. The invention also provides evidence of novel G-protein coupled receptors (GPCRs) related polynucleotide sequences whose expression level is associated with Parkinson's disease, Alzheimer's disease and leukemia. The present invention provides methods for identifying GPCR polypeptides associated with diseases and provides diagnostic compositions and methods for the detection of diseases.

20040067492, Apr 8, 2004

Oct 4, 2002

10/264378

Allan Peng - Palo Alto CA, US
James Love - Millbrae CA, US
Qianjin Hu - Castro Valley CA, US

C12Q001/68

435/006000

The present invention provides novel methods for detection of gene. A method for detecting RNA molecules of interest in which oligonucleotide primers uniquely complementary to specific RNA molecules are used as primers for reverse transcribing target RNAs with reverse transcriptase, or any enzyme that possesses reverse transcription activity, is provided. The invention eliminates the need for labeling or converting the target RNA by incorporating detectable labels in the elongation product of reverse transcription of the probe-bound target RNA in the sample.

20040175744, Sep 9, 2004

Feb 10, 2004

10/775920

Qianjin Hu - Castro Valley CA, US
Alan Peng - Palo Alto CA, US
Bin Liu - Castro Valley CA, US
James Love - Millbrae CA, US
Xiaofeng Hao - Chengdu, CN
Min Ren - Chengdu, CN
Zhumei Sheng - Chengdu, CN

C12Q001/68
G01N033/53
G01N033/574

435/006000, 435/007230

The present invention relates to the identification of the over expression of certain genes encoding certain secreted and membrane-bound proteins in breast, lung, colon and kidney cancers. Knowledge that these genes are over expressed in the cancers is useful for the detection, diagnosis, prevention and treatment of the specific cancers.