Inventors:
Rima L. McLeod - Chicago IL
Craig W. Roberts - Glasgow, GB
Fiona Roberts - Glasgow, GB
Jennifer J. Johnson - Stillwater MN
Michael Kirisits - Chicago IL
David Ferguson - Tackley Oxford, GB
Russell Lyons - Glasgow, GB
Ernest Mui - Chicago IL
Doug Mack - Riverside IL
Benjamin Samuel - Chicago IL
Piotr Gornicki - Chicago IL
Ellen Zuther - Beuhy, DE
Assignee:
Apicomplexan Therapeutics, LLC - Oak Lawn IL
International Classification:
C12Q 168
US Classification:
435 6, 435 72, 435 722, 435 196, 4351901, 4352542, 4353201, 435 691, 435 19, 536 237, 536 2374, 426 941, 4261851, 4262651, 4262661, 4262731
Abstract:
This invention relates uses of chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on chorismate synthase and its inhibitors.