Inventors:
Paul A. Rota - Decatur GA, US
Larry J. Anderson - Atlanta GA, US
William J. Bellini - Lilburn GA, US
Michael D. Bowen - Decatur GA, US
Cara Carthel Burns - Avondale Estates GA, US
Raymond Campagnoli - Decatur GA, US
Qi Chen - Marietta GA, US
James A. Comer - Decatur GA, US
Byron T. Cook - Augusta GA, US
Shannon L. Emery - Lusaka, ZM
Dean D. Erdman - Decatur GA, US
Cynthia S. Goldsmith - Lilburn GA, US
Jeanette Guarner - Decatur GA, US
Charles D. Humphrey - Lilburn GA, US
Joseph P. Icenogle - Atlanta GA, US
Thomas G. Ksiazek - Lilburn GA, US
Richard F. Meyer - Roswell GA, US
Stephan S. Monroe - Decatur GA, US
William Allan Nix - Bethlehem GA, US
M. Steven Oberste - Lilburn GA, US
Christopher D. Paddock - Atlanta GA, US
Teresa C. T. Peret - Atlanta GA, US
Pierre E. Rollin - Lilburn GA, US
Mark A. Pallansch - Lilburn GA, US
Anthony Sanchez - Lilburn GA, US
Wun-Ju Shieh - Norcross GA, US
Suxiang Tong - Alpharetta GA, US
Sherif R. Zaki - Atlanta GA, US
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC
International Classification:
C12Q 1/70
C07H 21/00
C12N 15/50
US Classification:
435 5, 536 2432, 536 2433
Abstract:
Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
