Philip M Triolo

6501549, Dec 31, 2002

Dec 3, 1998

09/077694

Joseph D. Andrade - Salt Lake City UT
Vladimir Hlady - Salt Lake City UT
Philip M. Triolo - Salt Lake City UT
Robert J. Scheer - Salt Lake City UT

University of Utah Research Foundation - Salt Lake City UT

G01B 1100

356388, 356392, 356394, 435 8

A method and associated apparatus for measuring chemical concentration in a liquid sample based on spatial separation and resolution of light is disclosed. The method is preferably applied to sensitive, quantitative, luminescence-based biosensors which reads the analyte concentration via spatial distribution of the emitted light. The detection of light is used to assess the spatial position, rather than the intensity or wavelength, of emitted light. A bioluminescent or chemiluminescent reaction requiring, for example, ATP, NADPH or NADH as a specific, and sensitive co-factor is used. ATP or NADH concentration is modulated, âtuned,â and/or regulated via, for example, an enzyme which consumes (âconsumaseâ) ATP, NADPH, or NADH, thereby producing a spatial distribution of ATP or NADH and a spatial distribution in the emitted light. By appropriate control of the consumase or âsynthaseâ activity and kinetics, a sensitive, specific, and easily readable luminescent pattern is produced, permitting detection.

52097323, May 11, 1993

Mar 4, 1991

7/664984

Fred P. Lampropoulos - Salt Lake City UT
Philip M. Triolo - Salt Lake City UT
William Padilla - Bennion UT

Merit Medical Systems, Inc. - Salt Lake City UT

A61M 2900

604 99

A locking syringe selectively operable in either of a freely reciprocating or a restricted, threaded mode. A trigger attached to the plunger includes internal threads on the interior of the barrel of the syringe and external threads located on the plunger on a spine slidable in a longitudinal slot in the plunger. A handle is affixed to the plunger, and a retraction bar is rigidly secured to the spine. The threads on the plunger may be retracted from engagement with the threads on the barrel, thereby placing the syringe in its freely reciprocating mode. The trigger, which is spring biased to engage the external and internal threads, employs a plurality of ramps and channels disposed at approximately the same angle to the longitudinal axes of the plunger and barrel as are the threads. A pawl is pivotally securable on the retraction bar at a position receivable into a pawl receiving aperture on the handle when the receiving bar is in its first position permitting reciprocating movement of the plunger. In this position, the pawl prevents the retraction bar from returning to its second position in which free movement of the plunger is precluded.

53245180, Jun 28, 1994

Mar 30, 1992

7/860434

Jeffrey L. Orth - Salt Lake City UT
Richard E. Hoffer - Park City UT
Philip M. Triolo - Salt Lake City UT

Biosynthesis, Inc. - Salt Lake City UT

A61K 922
A61M 532

424423

An implantable structure for incorporation into the tissues of a body is provided which retains therein fluid substances or biological substances which produce, or cause to be produced, biochemicals deliverable to the body. The implantable structure is configured to provide insertion and removal of substances therefrom as needed. The implantable structure generally comprises a porous outer member configured to encourage ingrowth of vascularized tissue therethrough, and an inner member of selectively permeable material providing interior space for inserting substances therein and which is structured to prevent ingrowth of tissue therethrough. The inner member is capable of providing immunoisolation to the substances therein as required.

51003929, Mar 31, 1992

Dec 8, 1989

7/447635

Jeffrey L. Orth - Salt Lake City UT
Richard E. Hoffer - Park City UT
Philip M. Triolo - Salt Lake City UT

Biosynthesis, Inc. - Salt Lake City UT

A61M 2500

604175

An implantable device for administering drugs or other substances to body tissues of a patient is disclosed. The device is designed to allow controlled ingrowth of connective tissue into the device, and a solution may be pumped or injected into the device where the solution is diffused through the ingrown connective tissue and out into the body.

45086060, Apr 2, 1985

May 16, 1983

6/495209

Joseph D. Andrade - Salt Lake City UT
Philip M. Triolo - Salt Lake City UT
Lee M. Smith - Salt Lake City UT
Frank J. Miller - Salt Lake City UT

C07C 324

204169

Surfaces of hydrophobic polymers are treated to reduce their friction resistance characteristics when in contact with an aqueous environment by exposing the surfaces to an oxidation treatment, preferably by use of radio frequency glow discharge. This oxidation is followed by exposure to atmospheric air, until there is a substantial reduction in the air-water contact angle of the surfaces. The reduced friction resistance characteristics are important in aqueous applications where there is movement between the surfaces of two polymeric materials, such as in double slideable catheters and similar medical products. This process also provides lower coefficients of friction for general polymeric products in contact with water and aqueous solutions.