US Patent:
20120322076, Dec 20, 2012
Inventors:
Peter Mushenheim - Cuyahoga Falls OH, US
Sagnik Basuray - Mishawaka IN, US
Gilad Yossifon - Mazkeret-Batia, IL
Satyajyoti Senapati - Mishawaka IN, US
Assignee:
University of Notre Dame du Lac - Notre Dame IN
International Classification:
G01N 27/26
G01N 27/403
G01N 33/50
G01N 27/02
US Classification:
435 612, 205775, 204406, 20440301
Abstract:
A microchamber electrochemical cell and method of using the cell for performing quantitative analysis of various charged macromolecules is presented. The microchamber electrochemical cell includes a substrate, opposing electrodes and at least one nanoslot. The substrate is configured to define a pair of opposing fluid reservoirs. The pair of opposing electrodes are respectively positioned within the opposing fluid reservoirs. Each nanoslot is configured to fluidly connect the opposing fluid reservoirs together. The opposing fluid reservoirs of the microchamber electrochemical cell are fluidly connected to each other only through each nanoslot. Each nanoslot is physically restricted to less than 500 nanometers. One method includes the steps of coupling, filling, measuring, obtaining, performing and preparing.