Paul L Valint

7625552, Dec 1, 2009

May 30, 2006

11/442773

Michael N. Helmus - Worcester MA, US
Paul Valint - Pittsford NY, US
Shrirang V. Ranade - Arlington MA, US

Boston Scientific Scimed, Inc. - Maple Grove MN

A61K 38/05
A61K 38/06
A61K 38/08
A61K 38/16
A61K 31/727
A61K 31/785
C08G 63/91

424 7827, 424423, 525 541, 525 542, 514 17, 514 18, 514 56, 530395

According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.

8221783, Jul 17, 2012

Sep 10, 2008

12/207839

Michael N. Helmus - Worcester MA, US
Yixin Xu - Newton MA, US
Barron W. Tenney - Haverhill MA, US
Paul L. Valint - Pittsford NY, US
Shrirang V. Ranade - Arlington MA, US

Boston Scientific Scimed, Inc. - Maple Grove MN

C08B 37/08
C08L 71/02
A61K 47/36
A61K 47/42
A61K 9/70
A61K 9/00
A61K 31/337
A61K 31/436
A61K 47/38
A61F 2/02
C07K 14/78
C08F 210/00
C08G 63/06
C08G 67/00
C08G 73/00
C08G 73/10

424434, 424422, 526348, 526258, 528367, 536 56, 536 30, 536 58, 536 3, 536 20, 525408, 530354, 5147723, 5147724, 5147726, 514291, 514279, 514449, 514777, 514779, 514781, 514773, 514774, 623 1111, 623 116, 623 146, 623 142, 623 136

Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.

20020075448, Jun 20, 2002

Dec 6, 2001

10/008441

Jay Kunzler - Canandaigua NY, US
Yu-Chin Lai - Pittsford NY, US
Joseph McGee - Dewitt NY, US
Paul Valint - Pittsford NY, US

G02C007/04
B05D005/06

351/16000R, 351/16000H, 427/162000, 427/164000

Biomedical devices are formed from the polymerization product of a monomeric mixture including a poly(2-oxazoline) endcapped with an ethylenically unsaturated radical, such as poly(2-oxazoline) macromonomers and telechelics. Preferred devices are ophthalmic lenses, especially contact lenses and intraocular lenses.

20020102415, Aug 1, 2002

May 20, 1999

09/315306

PAUL L. VALINT - PITTSFORD NY, US
DANIEL M. AMMON - ROCHESTER NY, US
JOSEPH A. MCGEE - DEWITT NY, US
GEORGE L. GROBE - PITTSFORD NY, US
RICHARD M. OZARK - SOLVAY NY, US

G02C007/02
B32B027/00
H05H001/00

428/447000, 428/446000, 428/421000, 427/533000, 427/536000, 427/539000, 351/16000H, 351/177000

The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.

20020120084, Aug 29, 2002

Nov 8, 2001

10/005560

Paul Valint - Pittsford NY, US
Joseph McGee - DeWitt NY, US
Joseph Salamone - Boca Raton FL, US
Richard Ozark - Solvay NY, US

C08F026/06

526/260000

The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.

20030039748, Feb 27, 2003

Mar 25, 2002

10/106083

Paul Valint - Pittsford NY, US
George Grobe - Pittsford NY, US
Daniel Ammon - Rochester NY, US
Michael Moorehead - Fairport NY, US

B05D005/06
B05D003/02
H05H001/24

427/162000, 427/397700, 427/569000

The present invention provides a method for treating a contact lens to provide an optically clear, hydrophilic coating upon the surface of a silicone hydrogel lens by subjecting the surface of the lens to a process comprising plasma treatment, hydration, and heat sterilization that is controlled to result in a silicate-containing film having a mosaic pattern of projecting plates surrounded by fissures when viewing a 50×50 micron square AFM image, wherein the peak-to-valley distances of the fissures are on average between about 100 and 500 angströms and the plate coverage is on average between about 40% to 99%.

20030068433, Apr 10, 2003

Apr 22, 2002

10/128172

Joseph McGee - Dewitt NY, US
Paul Valint - Pittsford NY, US
James Bonafini - Pittsford NY, US
Joseph Salamone - Boca Raton FL, US

B05D005/06
B05D003/12
A61L002/00

427/162000, 427/002100, 427/355000

The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device at reaction temperatures of less than about 55C.

20030224185, Dec 4, 2003

May 6, 2003

10/430826

Paul Valint - Pittsford NY, US
Daniel Ammon - Rochester NY, US
Joseph McGee - DeWitt NY, US
George Grobe - Pittsford NY, US
Richard Ozark - Solvay NY, US

Bausch & Lomb Incorporated - Rochester NY

B32B001/00

428/447000, 428/221000, 351/177000, 427/533000

The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.