US Patent:
20120244155, Sep 27, 2012
Inventors:
Patrick Lecine - Dallas TX, US
Yves Levy - Paris, FR
Gerard Zurawski - Midlothian TX, US
Jacques F. Banchereau - Montclair NJ, US
Assignee:
BAYLOR RESEARCH INSTITUTE - Dallas TX
Agence Nationale de Recherches Sur le Sida - Paris
Institut National de la Sante et de la Recherche Medicale (INSERM) - Paris
International Classification:
A61K 39/395
A61P 37/04
C12N 5/078
Abstract:
Compositions and methods comprising high affinity monoclonal antibody conjugates against several DC receptors are described herein. The inventors prepared fusion proteins with antigens for DC-targeting vaccine generation by conjugating several protein antigens with high affinity monoclonal antibodies against several DC receptors with a view to developing novel human vaccines based on in vivo DC-targeting. The findings of studies described herein indicate that vaccines bearing TB antigens can recall a potent memory antigen-specific T cell response in vitro resulting in IFNγ secretion.