Resumes
Resumes
Parnian Zia-Amirhosseini Phones & Addresses
-
Thousand Oaks, CA
Publications
Us Patents
Methods For Administering Anti-Il-5 Antibodies
View pageUS Patent:
20100086547, Apr 8, 2010
Filed:
Apr 30, 2008
Appl. No.:
12/598309
Inventors:
Bela Rajiv Patel - King of Prussia PA, US
Deborah Smith - Durham NC, US
Debra J. Tompson - King of prussia PA, US
Parnian Zia-Amirhosseini - Thousand Oaks CA, US
Deborah Smith - Durham NC, US
Debra J. Tompson - King of prussia PA, US
Parnian Zia-Amirhosseini - Thousand Oaks CA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 39/395
US Classification:
4241331, 4241581
Abstract:
The present invention relates generally to the methods for the treatment and diagnosis of conditions mediated by IL-5 and excess eosinophil production, and more specifically to mAbs, Fabs, chimeric and humanized antibodies. More particularly, methods are provided for reducing eosinophils in a human in need thereof, which method comprises administering to said human a composition comprising at least one anti-IL-5 antibody, wherein at least one anti-IL-5 antibody provides a mean maximum plasma concentration of said anti-IL-5 antibody of at least about 1.030.21 μg/mL, an Area Under the Curve value of at least about 15.52.7 μg/day/mL and a serum half-life of about 16.22.1 days to about 21.72.8 days.