Inventors:
Kirk J. Leister - Fayetteville NY, US
Eugene J. Schaefer - Westfield NJ, US
Ronald Charles Bates - Irvine CA, US
Elizabeth A. Bramhall - Groton MA, US
David Michael Didio - Syracuse NY, US
Robert Donaldson - Southborough MA, US
Alan R. Flesher - Lawrenceville NJ, US
Helen Gray Haggerty - Manlius NY, US
David Henry Kirkley - East Syracuse NY, US
John Malcolm Tabor - Syracuse NY, US
Lee K. Tay - Princeton Junction NJ, US
Pallaiah Thammana - Manlius NY, US
Ajoy Velayudhan - Cary NC, US
David Edward Smolin - Pennington NJ, US
Reb J. Russell - Doylestown PA, US
Thomas James Vanden Boom - Flemington NJ, US
Dean Woodrow Brownell - Oswego NY, US
Jeffrey Schrimsher - Hillsborough NC, US
Joyce Patricia Whitehead - Manlius NY, US
International Classification:
A61K 39/395
C07K 16/18
C12P 21/00
C07K 1/14
C07K 1/18
US Classification:
4241781, 5303911, 435 691, 530412, 530416
Abstract:
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.