US Patent:
20100152098, Jun 17, 2010
Inventors:
Tomasz Glinka - Cupertino CA, US
Olga Rodny - Mountain View CA, US
Keith A. Bostian - Atherton CA, US
David M. Wallace - San Diego CA, US
Robert I. Higuchi - Solana Beach CA, US
Chun Chow - San Diego CA, US
Chi Ching Mak - San Diego CA, US
Gavin Hirst - San Diego CA, US
Brian Eastman - San Diego CA, US
Assignee:
Mpex Pharmaceuticals, Inc. - San Diego CA
International Classification:
A61K 38/05
A61K 38/02
C07D 265/30
C07D 241/42
C07D 215/38
C07D 211/58
C07D 211/06
C07D 213/643
C07D 213/74
C07D 231/12
C07D 209/20
C07D 207/14
C07D 333/24
C07D 321/10
C07D 319/18
C07D 309/10
C07D 307/79
C07C 311/46
C07C 237/20
A61P 31/08
A61P 31/06
A61P 31/04
C07D 217/22
A61K 31/472
US Classification:
514 8, 544166, 544353, 546163, 546171, 546223, 546234, 546291, 546309, 5483771, 548503, 548540, 549 77, 549350, 549362, 549416, 549469, 564 86, 564153, 546143, 514310, 514 19
Abstract:
Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.