US Patent:
20110319317, Dec 29, 2011
Inventors:
Joseph Collard - Delray Beach FL, US
Olga Khorkova Sherman - Tequesta FL, US
Carlos Coito - West Palm Beach FL, US
Belinda De Leon - San Francisco CA, US
Assignee:
OPKO CuRNA, LLC - Miami FL
International Classification:
A61K 31/713
A61P 35/00
A61P 25/28
A61P 25/14
A61P 25/16
A61P 25/00
A61P 21/00
A61P 3/00
A61P 5/50
A61P 3/10
A61P 3/04
A61P 3/08
A61P 7/00
A61P 3/06
A61P 19/10
A61P 35/02
A61P 1/16
A61P 25/32
A61P 31/14
A61P 27/02
A61P 9/10
A61P 9/04
A61P 1/04
A61P 29/00
A61P 1/00
A61P 19/04
A61P 19/02
A61P 11/00
A61Q 19/08
A61P 13/00
A61P 17/00
C12N 5/071
C12Q 1/68
C07H 21/02
US Classification:
514 16, 514 44 A, 536 245, 514 193, 514 194, 514 195, 514 178, 514 177, 514 179, 514 67, 514 69, 514 48, 514 68, 514 74, 514 169, 514 196, 514 43, 514 208, 514 19, 514 164, 514 132, 514 166, 514 168, 514 188, 514 186, 435375, 435 612
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sirtuin 1 (SIRT1), in particular, by targeting natural antisense polynucleotides of Sirtuin 1 (SIRT1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SIRT 1.