Inventors:
Nnochiri Nkem Ekwuribe - Cary NC
Jennifer A. Riggs-Sauthier - Raleigh NC
Assignee:
Nobex Corporation - Durham NC
International Classification:
A61K 31655
US Classification:
514150, 534660, 534852, 534853
Abstract:
Compounds are disclosed having the structure of Formula I: where R , R , and R are independently hydrogen or C to C alkyl, and R is: where R is selected from the group consisting of hydrogen and C to C alkyl, or where R , R and R are independently hydrogen or C to C alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R , R and R are independently selected from the group consisting of hydrogen and C to C alkyl, and R is selected from the group consisting of hydrogen and âC(O)R , where R is a C to C alkyl or an aryl group.