Inventors:
George A. Digenis - Lexington KY
Nikolaos P. Rodis - Lexington KY
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
C07D25702
A61K 3141
Abstract:
A compound of the formula ##STR1## wherein R and R' together represent a primary or a secondary aliphatic amine. Also described are elastase enzyme inhibitory compositions including a carrier and an elastase enzyme inhibiting amount of the compounds of the invention. A method of selectively inhibiting the enzyme elastase in an animal or a human in need of such treatment includes administering to the animal or human an enzyme elastase inhibiting amount of one of the compounds of the invention or a composition thereof.