Nicholas H Weber

20090285827, Nov 19, 2009

Jul 24, 2009

12/508618

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Erika L. F. Holzbaur-Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newton Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas N. Pangalos - Pennington NJ, US

Wyeth - Madison NJ
The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 39/395
G01N 33/53

4241451, 435 71

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

20120016106, Jan 19, 2012

Mar 2, 2011

13/038954

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas N. Pangalos - Pennington NJ, US

Wyeth LLC - Madison NJ

C07K 16/00
C12N 5/10
C07H 21/04
C12N 1/19
C12N 15/63
C12P 21/06
C12N 1/21

5303871, 435 696, 435325, 435352, 435358, 435365, 435367, 4352523, 43525231, 43525233, 4352542, 43525421, 43525422, 4353201, 536 2353

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

20070087000, Apr 19, 2007

Aug 14, 2006

11/503062

Frank Walsh - Bryn Mawr PA, US
Margaret Zaleska - Narberth PA, US
David Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas Pangalos - Pennington NJ, US
William Kelley - Reading MA, US

A61K 39/395
C07K 16/22

424145100, 530388250

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

20120003212, Jan 5, 2012

Feb 18, 2011

13/030978

FRANK S. WALSH - BRYN MAWR PA, US
MARGARET M. ZALESKA - NARBERTH PA, US
DAVID S. HOWLAND - YARDLEY PA, US
LIOUDMILA TCHISTIAKOVA - ANDOVER MA, US
RIYEZ KARIM - NORTH ANDOVER MA, US
PAMELA KELLEY - READING MA, US
XIANG-YANG TAN - READING MA, US
SEUNG POON KWAK - EWING NJ, US
KAREN WALLACE - NEWTOWN SQUARE PA, US
NICHOLAS WEBER - MOUNTAINTOP PA, US
MENELAS N. PANGALOS - PENNINGTON NJ, US
WILLIAM KELLEY - READING MA, US

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - PHILADELPHIA PA
WYETH LLC - MADISON NJ

A61K 39/395
A61P 21/00

4241331, 4241581

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.