US Patent:
20040096917, May 20, 2004
Inventors:
Richard Ivey - Parkton MD, US
Thomas Gentle - Red Lion PA, US
Richard Moore - Glenville PA, US
Michael Towns - Timonium MD, US
Nicholas Bachur - Monkton MD, US
Robert Rosenstein - Ellicott City MD, US
James Nadeau - Ellicott City MD, US
Paul Goldenbaum - Hampstead MD, US
Song Shi - Reisterstown MD, US
Donald Copertino - Catonsville MD, US
James Garrett - Baltimore MD, US
Gregory Tice - Lutherville MD, US
Assignee:
Becton, Dickinson and Company - Franklin Lakes NJ
International Classification:
G01N033/554
G01N033/569
Abstract:
The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.