Resumes
Resumes
Nichol Holodick Phones & Addresses
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Mattawan, MI
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Kalamazoo, MI
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Port Washington, NY
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Kingston, PA
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98 Linden St, Roslyn Hts, NY 11577 (516) 312-7729
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Roslyn Heights, NY
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Lawrence, NY
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Boston, MA
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Mount Morris, PA
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Roslyn Hts, NY
Publications
Us Patents
Human B1 Cells And Uses Thereof
View pageUS Patent:
20130202624, Aug 8, 2013
Filed:
Sep 22, 2011
Appl. No.:
13/825375
Inventors:
Rothstein L. Thomas - Port Washington NY, US
Daniel O. Griffin - Port Washington NY, US
Nichol E. Holodick - Roslyn Heights NY, US
Daniel O. Griffin - Port Washington NY, US
Nichol E. Holodick - Roslyn Heights NY, US
International Classification:
C12N 5/0781
A61K 39/395
G01N 33/68
A61K 39/395
G01N 33/68
US Classification:
4241731, 4353431, 435 792, 5303896, 435 612
Abstract:
The present invention is directed to isolated populations of human natural immunoglobulin-producing B1 lymphocytes, wherein the B1 lymphocytes display surface biomarkers CD20, CD43 and CD27 and are either CD11b+ or GD11b−. The present invention is also directed to a method of isolating human natural immunoglobulin-producing B1 lymphocytes from a blood sample comprising isolating B lymphocytes from the sample that express surface biomarkers CD20, CD43 and CD27, and, optionally, CD11b. In addition, the present invention is directed to a methods for diagnosing a B1 cell disorder in a patient, determining the prognosis of a patient having a B1 cell disorder, and treating a patient having a B1 cell disorder.