Resumes
Resumes
Neil Segil Phones & Addresses
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Dover, NH
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Lee, NH
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Inglewood, CA
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2440 Santa Rosa Ave, Altadena, CA 91001 (626) 665-9550
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New York, NY
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Marblehead, MA
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2440 Santa Rosa Ave, Altadena, CA 91001
Publications
Us Patents
Cells That Lack P19Ink4D And P27Kip1 Activity And Methods Of Use Thereof
View pageUS Patent:
6589505, Jul 8, 2003
Filed:
Jan 14, 2000
Appl. No.:
09/483597
Inventors:
Martine F. Roussel - Memphis TN
Richard Smeyne - Collierville TN
Frederique Zindy - Memphis TN
Justine Cunningham - Memphis TN
Neil Segil - Altadena CA
Ping Chen - Arcadia CA
Richard Smeyne - Collierville TN
Frederique Zindy - Memphis TN
Justine Cunningham - Memphis TN
Neil Segil - Altadena CA
Ping Chen - Arcadia CA
Assignee:
St. Jude Childrens Research Hospital - Memphis TN
International Classification:
A61K 4900
US Classification:
424 92, 424 91, 435325, 4353201, 435375, 800 3, 800 8, 800 9, 800 14
Abstract:
Non-human animals that have been manipulated so as not to express a functional p19 and p27 proteins are described. One particular non-human animal exemplified is a p19 -double null, p27 -double null mouse. Such knockout mice exhibit bradykinesia, proprioceptive abnormalities, seizure-like activity, and generally die 14-24 days after birth. In addition, mammalian cells having the p19 -double null, p27 -double null genotype are characterized. Methods of making and using the non-human knockout animals and cells are disclosed.
Activation Of Yap Signaling For Sensory Receptor Regeneration
View pageUS Patent:
20210324412, Oct 21, 2021
Filed:
Apr 15, 2021
Appl. No.:
17/231328
Inventors:
- Los Angeles CA, US
Neil I. SEGIL - Altadena CA, US
Xizi WANG - Arcadia CA, US
Neil I. SEGIL - Altadena CA, US
Xizi WANG - Arcadia CA, US
International Classification:
C12N 15/86
A61K 9/00
C12N 7/00
A61P 27/16
A61K 9/00
C12N 7/00
A61P 27/16
Abstract:
A method for inducing sensory receptor regeneration includes a step of identifying a subject in need of regeneration of inner ear sensory epithelia. Yap/Tead signaling in the subject is then activated. Typically, Yap/Tead signaling is activated by introducing an expression vector into the subject such that the expression vector contacts inner ear sensory epithelia in a sufficient amount to induce regeneration thereof. Characteristically, the expression vector encodes a constitutively active YAP gene.