Inventors:
- Horsham PA, US
Johan Fransson - Toronto, CA
Natalie Fursov - Harleysville PA, US
Damon Hamel - San Diego CA, US
Thomas Malia - Philadelphia PA, US
Galina Obmolova - Phoenixville PA, US
Tatiana Ort - Plymouth Meeting PA, US
Michael Rycyzyn - Berwyn PA, US
Michael Scully - Medford NJ, US
Raymond Sweet - Bryn Mawr PA, US
Alexey Teplyakov - Phoenixville PA, US
John Wheeler - Devon PA, US
Juan Carlos Almagro - Brookline MA, US
International Classification:
C07K 16/28
Abstract:
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.