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Nagasree N Chakka

from Lexington, MA
Age ~50
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Also known as:
E Chakka
Phone and address:
16 Wellington Lane Ave, Lexington, MA 02421
Connected to:
Jyothi S Chakka, 47Vinod K Chakka, 45Noel F Chakkalakal, 48Smrithi A Chakkalakal, 36Roopa R Chakkappan, 48Naresh K Chakkirala, 55Salima Chakkiwala, 40Abhijit Chakladar, 60Ronald M Chakler, 70Ashish Chakma, 48

Nagasree Chakka Phones & Addresses

  • 16 Wellington Lane Ave, Lexington, MA 02421
  • Waltham, MA
  • Quincy, MA

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Resumes

Nagasree Chakka Photo 1

Associate Scientist At Amgen

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Location:
P/O Box 1027, Millbrook, AL
Industry:
Biotechnology
Work:
Amgen
Associate Scientist at Amgen
Nagasree Chakka Photo 2

Nagasree Chakka

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Nagasree Chakka Photo 3

Nagasree Chakka

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Publications

Us Patents

Spiro-Oxindole Compounds And Their Use As Therapeutic Agents

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US Patent:
8263606, Sep 11, 2012
Filed:
Oct 13, 2009
Appl. No.:
12/578148
Inventors:
Mikhail Chafeev - Burnaby, CA
Sultan Chowdhury - Surrey, CA
Lauren Fraser - Surrey, CA
Jianmin Fu - Coquitlam, CA
Jonathan Langille - Quaker Hill CT, US
Shifeng Liu - Coquitlam, CA
Jianyu Sun - San Mateo CA, US
Shaoyi Sun - Coquitlam, CA
Serguei Sviridov - Burnaby, CA
Mark Wood - Port Moody, CA
Alla Zenova - Vancouver, CA
Qi Jia - Burnaby, CA
Jean-Jacques Cadieux - Burnaby, CA
Simon J. Gauthier - Vancouver, CA
Amy Frances Douglas - Vancouver, CA
Tom Hsieh - Toronto, CA
Nagasree Chakka - Waltham MA, US
Zoran Cikojevic - Port Coquitlam, CA
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby
International Classification:
A61K 31/44
C07D 213/02
US Classification:
514278, 546 15
Abstract:
This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

N-Piperidinyl Acetamide Derivatives As Calcium Channel Blockers

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US Patent:
8377968, Feb 19, 2013
Filed:
Apr 8, 2009
Appl. No.:
12/420793
Inventors:
Hassan Pajouhesh - West Vancouver, CA
Ramesh Kaul - Burnaby, CA
Yanbing Ding - Richmond, CA
Yongbao Zhu - Langley, CA
Lingyun Zhang - Vancouver, CA
Nagasree Chakka - Cambridge MA, US
Mike Grimwood - North Vancouver, CA
Jason Tan - Vancouver, CA
Yuanxi Zhou - Richmond, CA
Assignee:
Zalicus Pharmaceuticals, Ltd. - Vancouver, BC
International Classification:
A61K 31/454
A61K 31/445
A61P 25/08
A61P 25/16
A61P 25/18
A61P 25/30
A61P 25/00
A61P 3/10
A61P 29/00
A61P 35/00
A61P 13/10
A61P 13/12
A61P 15/16
US Classification:
514326, 514331, 514316, 546247, 546203
Abstract:
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

Spiro-Oxindole Compounds And Their Uses As Therapeutic Agents

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US Patent:
8415370, Apr 9, 2013
Filed:
Jul 25, 2012
Appl. No.:
13/557833
Inventors:
Mikhail Chafeev - Himki, RU
Sultan Chowdhury - Surrey, CA
Lauren Fraser - Surrey, CA
Jianmin Fu - Coquitlam, CA
Jonathan Langille - Quaker Hill CT, US
Shifeng Liu - Coquitlam, CA
Jianyu Sun - Burnaby, CA
Shaoyi Sun - Coquitlam, CA
Serguei Sviridov - Burnaby, CA
Mark Wood - Port Moody, CA
Alla Yurevna Zenova - Vancouver, CA
Qi Jia - Burnaby, CA
Jean-Jacques Cadieux - Burnaby, CA
Simon J. Gauthier - Vancouver, CA
Amy Frances Douglas - Saskatoon, CA
Tom Hsieh - Burnaby, CA
Nagasree Chakka - Waltham MA, US
Zoran Cikojevic - Port Coquitlam, CA
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby, BC
International Classification:
A61K 31/44
C07D 213/02
US Classification:
514278, 546 15
Abstract:
This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

Use Of Spiro-Oxindole Compounds As Therapeutic Agents

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US Patent:
8466188, Jun 18, 2013
Filed:
Oct 12, 2007
Appl. No.:
12/445264
Inventors:
Mikhail Chafeev - Burnaby, CA
Sultan Chowdhury - Surrey, CA
Robert Fraser - North Vancouver, CA
Jianmin Fu - Coquitlam, CA
Rajender Kamboj - Burnaby, CA
Duanjie Hou - Burnaby, CA
Shifeng Liu - Coquitlam, CA
Mehran Seid Bagherzadeh - Vancouver, CA
Serguei Sviridov - Burnaby, CA
Shaoyi Sun - Coquitlam, CA
Jianyu Sun - San Mateo CA, US
Nagasree Chakka - Waltham MA, US
Tom Hsieh - Toronto, CA
Vandna Raina - Gurgaon, IN
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby, BC
International Classification:
A61K 31/40
A61K 31/5377
US Classification:
514409, 5142328, 514256, 514321, 514338
Abstract:
This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R, R, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

Spiro-Oxindole Compounds And Their Uses As Therapeutic Agents

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US Patent:
20100125072, May 20, 2010
Filed:
Dec 30, 2009
Appl. No.:
12/650196
Inventors:
Mikhail Chafeev - Burnaby, CA
Nagasree Chakka - Waltham MA, US
Sultan Chowdhury - Surrey, CA
Robert Fraser - North Vancouver, CA
Jianmin Fu - Coquitlam, CA
Duanjie Hou - Burnaby, CA
Tom Hsieh - Toronto, CA
Rajender Kamboj - Burnaby, CA
Shifeng Liu - Coquitlam, CA
Vandna Raina - Gurgaon, IN
Mehran Seid Bagherzadeh - Vancouver, CA
Jianyu Sun - San Mateo CA, US
Shaoyi Sun - Coquitlam, CA
Serguei Sviridov - Burnaby, CA
Assignee:
XENON PHARMACEUTICALS INC. - Burnaby
International Classification:
A61K 31/5377
C07D 491/10
A61K 31/407
A61K 31/4439
A61K 31/506
US Classification:
5142328, 548410, 514409, 546 15, 514278, 544230, 514256, 544 70
Abstract:
This invention is directed to spiro-oxindole compounds of formula (I):wherein k, j, Q, RR, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.

N-Piperidinyl Acetamide Derivatives As Calcium Channel Blockers

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US Patent:
20130065926, Mar 14, 2013
Filed:
Aug 31, 2012
Appl. No.:
13/601357
Inventors:
Hassan A. PAJOUHESH - West Vancouver, CA
Ramesh KAUL - Burnaby, CA
Yanbing DING - Richmond, CA
Yongbao ZHU - Langley, CA
Lingyun ZHANG - Vancouver, CA
Nagasree CHAKKA - Cambridge MA, US
Michael Edward GRIMWOOD - North Vancouver, CA
Jason TAN - Vancouver, CA
Yuanxi ZHOU - Richmond, CA
International Classification:
A61K 31/445
A61P 29/00
US Classification:
514331
Abstract:
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing N-piperidinyl acetamide derivatives as shown in formula (1).

Pyridyl Derivatives And Their Use As Therapeutic Agents

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US Patent:
20130079354, Mar 28, 2013
Filed:
Sep 14, 2012
Appl. No.:
13/620151
Inventors:
Melwyn ABREO - Jamul CA, US
Daniel F. HARVEY - San Diego CA, US
Mikhail A. KONDRATENKO - San Diego CA, US
Wenbao LI - San Diego CA, US
Rajender KAMBOJ - Burnaby, CA
Vishnumurthy KODUMURU - Waltham MA, US
Michael D. WINTHER - Vancouver, CA
Heinz W. GSCHWEND - Santa Rosa CA, US
Nagasree CHAKKA - Waltham MA, US
Shifeng LIU - Port Coquitlam, CA
Serguei SVIRIDOV - Burnaby, CA
Shaoyi SUN - Vancouver, CA
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby
International Classification:
C07D 401/14
C07D 401/04
US Classification:
51425313, 544365, 544364, 435184
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):wherein W, V, x, y, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

Carboxamides As Inhibitors Of Voltage-Gated Sodium Channels

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US Patent:
20130131035, May 23, 2013
Filed:
Feb 16, 2011
Appl. No.:
13/575912
Inventors:
Howard Bregman - Melrose MA, US
John L. Buchanan - Newton MA, US
Nagasree Chakka - Lexington MA, US
Erin F. Dimauro - Cambridge MA, US
Bingfan Du - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Xiao Mei Zheng - Natick MA, US
Assignee:
AMGEN INC. - Thousand Oaks CA
International Classification:
C07D 471/10
C07D 401/04
C07D 403/04
C07D 251/48
US Classification:
5142102, 544209, 514245, 5462681, 544323, 514275
Abstract:
The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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Nagasree N Chakka from Lexington, MA, age ~50 Get Report