US Patent:
20130079354, Mar 28, 2013
Inventors:
Melwyn ABREO - Jamul CA, US
Daniel F. HARVEY - San Diego CA, US
Mikhail A. KONDRATENKO - San Diego CA, US
Wenbao LI - San Diego CA, US
Rajender KAMBOJ - Burnaby, CA
Vishnumurthy KODUMURU - Waltham MA, US
Michael D. WINTHER - Vancouver, CA
Heinz W. GSCHWEND - Santa Rosa CA, US
Nagasree CHAKKA - Waltham MA, US
Shifeng LIU - Port Coquitlam, CA
Serguei SVIRIDOV - Burnaby, CA
Shaoyi SUN - Vancouver, CA
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby
International Classification:
C07D 401/14
C07D 401/04
US Classification:
51425313, 544365, 544364, 435184
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):wherein W, V, x, y, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.