Murray E Jarvik

58340114, Nov 10, 1998

Jun 7, 1995

8/479812

Karce Daniel Rose - Healdsburg CA
Jed E. Rose - Venice CA
Murray E. Jarvik - Santa Monica CA

The Regents of the University of California - Oakland CA

A61F 1300

424449

A method of aiding in the reduction of the incidence of tobacco smoking which comprises, in one embodiment, the application of a nicotine containing dermally applicable patch such that the nicotine in the patch is allowed to transdermally migrate into the bloodstream at a rate sufficient to correspond to the nicotine level in the blood achieved by tobacco smoking. Simultaneously therewith, the method involves the oral application of a low concentration nicotine aerosol spray having a selected droplet size and selected concentration of nicotine. In another embodiment, the invention resides in the use of the transdermal application of nicotine alone and in a further embodiment, the method resides in the use of the low concentration nicotine aerosol spray alone. Further, a device for applying the low dose nicotine aerosol spray is also provided.

50166522, May 21, 1991

Feb 19, 1988

7/157627

Jed E. Rose - Venice CA
Murray E. Jarvik - Santa Monica CA

The Regents of the University of California - Berkely CA

A24F 4700

131270

A dermally applicable patch adapted for application to the skin of the user to enable a transdermal administration to the bloodstream of a user. The patch comprises an outer layer which is impermeable to the passage of nicotine and an inner layer which may operate as a rate controlling membrane to allow the passage of nicotine into the bloodstream of a user. An outer layer and an inner layer form a nicotine receiving area for receiving the nicotine to thereby allow the same to pass through the inner layer. In a preferred embodiment, the patch is highly effective in reducing the incidence of tobacco smoking by allowing transdermal nicotine migration into the bloodstream of a user at a rate sufficient to correspond to the nicotine level in the blood achieved by smoking.

49535722, Sep 4, 1990

Feb 19, 1988

7/157948

Jed E. Rose - Durham NC
Murray E. Jarvik - Santa Monica CA
Karce D. Rose - Healdsburg CA

A24F 4700

131270

A method and a composition for aiding in the reduction of the incidence of tobacco smoking which comprises a method of administering a nicotine containing aerosol spray to the oral cavity of an individual to provide a stimulation to the respiratory tract of the smoker, somewhat similar to that provided by normal tobacco smoke. The method also comprises a composition of a low concentration nicotine aerosol spray in which the spray droplets have a size and a range of between about one micron to about ten microns in diameter and which spray preferably contains nicotine in an amount of about 0. 005 miligrams to about 0. 03 miligrams per inhilation.

49209892, May 1, 1990

Feb 19, 1988

7/157536

Jed E. Rose - Venice CA
Murray E. Jarvik - Santa Monica CA
Karce D. Rose - Healdsburg CA

Regents of the University of California - Alameda CA

A24F 4700
A61K 900

131270

A method of aiding in the reduction of incidence of tobacco smoking. The method comprises applying a patch containing nicotine to the skin of a person with whom smoking reduction is desired and allowing the nicotine to transdermally migrate into the person's bloodstream to achieve a desired systemic nicotine level. The method also comprises the simultaneous administration of a nicotine containing aerosol spray to the oral cavity of the user in order to provide the desired sensations in the respiratory tract to which the user is accustomed from normal tobacco smoke. A combination of the spray and transdermal patch is also provided such that an occlusive patch is applied to the skin of the person with whom smoking reduction is desired and the nicotine containing aerosol spray is delivered to the oral cavity simultaneously with the application of the nicotine from the patch.