Inventors:
Sam J. Milstein - Larchmont NY
John E. Smart - Katonah NY
Donald J. Sarubbi - Carmel NY
Monica Leipold - Thornwood NY
Elizabeth Flanders - Ridgefield CT
Doris OToole - Carmel NY
David Gschneidner - Stamford CT
Assignee:
Emisphere Technologies, Inc. - Tarrytown NY
International Classification:
A61K 3828
US Classification:
514 3, 514 2, 514 11, 514 12, 514 21, 514 56, 514563
Abstract:
The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.