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Mitchell R Malachowski

from San Diego, CA
Age ~69

Mitchell Malachowski Phones & Addresses

  • 1015 Cordova St, San Diego, CA 92107 (619) 224-2921
  • 828 Temple St, San Diego, CA 92106
  • 1015 Cordova St, San Diego, CA 92107

Work

Company: Gordon & Rees Address: 200 W Broadway Ste 2000, San Diego, CA 92101 Specialities: Litigation - 34% • Environmental / Natural Resources - 33% • Construction / Development - 33%

Education

School / High School: Pepperdine University School of Law

Ranks

Licence: California - Active Date: 2006

Emails

Specialities

Construction / Development • Environmental/Toxic Tort • Commercial Litigation

Professional Records

Lawyers & Attorneys

Mitchell Malachowski Photo 1

Mitchell B Malachowski, San Diego CA - Lawyer

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Address:
Gordon & Rees
200 W Broadway Ste 2000, San Diego, CA 92101
(619) 696-6700 (Office), (619) 696-7124 (Fax)
Licenses:
California - Active 2006
Education:
Pepperdine University School of Law
University of Maryland
Specialties:
Litigation - 34%
Environmental / Natural Resources - 33%
Construction / Development - 33%
Mitchell Malachowski Photo 2

Mitchell Malachowski - Lawyer

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Office:
Gordon Rees Scully Mansukhani, LLP
Specialties:
Construction / Development
Environmental/Toxic Tort
Commercial Litigation
ISLN:
919585216
Admitted:
2006
University:
University of Maryland, B.S., 2003
Law School:
Pepperdine University School of Law, J.D., 2006

Publications

Us Patents

Composition, Synthesis And Therapeutic Applications Of Polyamines

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US Patent:
20050085555, Apr 21, 2005
Filed:
Dec 18, 2002
Appl. No.:
10/499931
Inventors:
Michael Murphy - La Jolla CA, US
Mitchell Malachowski - San Diego CA, US
International Classification:
A61K031/13
US Classification:
514674000
Abstract:
This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

Therapeutic Polyamine Compositions And Their Synthesis

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US Patent:
20140057877, Feb 27, 2014
Filed:
Oct 18, 2011
Appl. No.:
13/276133
Inventors:
Michael A. Murphy - Cardiff CA, US
Mitchell R. Malachowski - San Diego CA, US
International Classification:
C07F 9/50
C07D 295/13
C07D 213/36
C07C 323/25
C07D 295/03
C07C 211/14
C07C 211/19
US Classification:
514107, 514674, 564512, 546186, 514316, 544357, 51425211, 564460, 514661, 564501, 514665, 540474, 514183, 564 15, 514108, 546264, 514332
Abstract:
This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

Composition, Synthesis And Therapeutic Applications Of Polyamines

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US Patent:
20030013772, Jan 16, 2003
Filed:
Dec 18, 2001
Appl. No.:
10/017235
Inventors:
Michael Murphy - La Jolla CA, US
Mitchell MaLachowski - San Diego CA, US
International Classification:
A61K031/13
C07C211/14
US Classification:
514/674000, 564/512000
Abstract:
The invention relates to the preparation of novel polyamines, such as derivatives of 1,3-bis-[(2′-aminoethyl)-amino]propane (2,3,2-tetramine) and 1,4,8,11-tetraazacyclotetradecane (cyclam), which can be used to treat mitochondrial and degenerative diseases. Accordingly, in one aspect the invention is directed to compounds of the formula: wherein R, R, R, R, Rand Rmay be the same or different and are hydrogen, alkyl, aryl, cycloalkyl, amino acid, glutathione, urate, ascorbate, estrogen, dehydroepiandrosterone, redox stabilizing substituents, a quinone, glutamate, succinate, —(CH)[XCH)]NH— wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon, or heterocycle wherein Rto Rtaken together are —(CHXCH)— wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon. M, n, and p may be the same or different and are bridging groups of variable length from 3-12 carbons. Xand Xmay be the same or different and are nitrogen, sulfur, phosporous or carbon.
Mitchell R Malachowski from San Diego, CA, age ~69 Get Report