US Patent:
20060128682, Jun 15, 2006
Inventors:
Ralph Zingaro - College Station TX, US
Hatice Duzkale - Houston TX, US
Emil Freireich - Houston TX, US
Hagop Kantarjian - Bellaire TX, US
Merida Sotelo-Lerma - Hermosillo, MX
Srdan Verstovsek - Houston TX, US
Mingzhang Gao - Indianapolis IN, US
Assignee:
The Texas A&M University System - College Station TX
Board of Regents, The University of Texas System - Austin TX
International Classification:
C07F 9/90
A61K 31/555
A61K 31/285
US Classification:
514184000, 514504000, 546002000, 556070000
Abstract:
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.