Milton Blake Hammond

6838584, Jan 4, 2005

May 6, 2002

10/475079

Timothy Allen Blizzard - Middletown NJ, US
Milton Lloyd Hammond - Somerville NJ, US
Jerry Dwain Morgan - Sayreville NJ, US
Ralph Troy Mosley - Roselle NJ, US

Merck & Co., Inc. - Rahway NJ

C07C 3912
C07D22118
C07D21106
A61K 3144
A61K 3105

568719, 568721, 546 38, 546195, 514279, 514732, 514738

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

20030225132, Dec 4, 2003

Mar 11, 2003

10/385808

Frank DiNinno - Old Bridge NJ, US
Milton Hammond - Somerville NJ, US

A61K031/453
A61K031/4025
C07D411/02

514/321000, 514/422000, 546/197000, 548/526000

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

20040082642, Apr 29, 2004

Nov 14, 2003

10/433271

Konrad Koehler - Huddinge, SE
Mikael Gillner - Stockholm, SE
Ye Liu - Tullinge, SE
Aiping Cheng - Huddinge, SE
James Heck - Rahway NJ, US
Milton Hammond - Somerville NJ, US
Ralph Mosley - Rahway NJ, US
Mahmoud Rahimi-Ghadim - Stockholm, SE

C07D209/54
A61K031/407

514/409000, 548/408000

The present invention relates to compounds of formula (I) and derivatives thereof, in which the variables are as defined in the claims, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynecomastia, autoimmune disease, vascular smooth muscle cell profileration, obesity, incontinence, and cancer of the lung, colon, breast, uterus, and prostate.

20040259850, Dec 23, 2004

Apr 30, 2004

10/494548

Stephen Alves - New York NY, US
Milton Hammond - Somerville NJ, US
Samuel Wright - Westfield NJ, US

A61K031/56

514/169000

A tachykinin receptor antagonist, in particular a neurokinin-1 receptor antagonist, is useful for the treatment or prevention of hot flashes associated with hormonal variation in a patient.

20060183744, Aug 17, 2006

Sep 15, 2003

10/528212

Susan Rohrer - Scotch Plains NJ, US
Milton Hammond - Branchburg NJ, US

A61K 31/50
A61K 38/22
A61K 31/137
A61K 31/59
A61K 31/496

514247000, 514649000, 514253030, 514253040, 514167000, 514002000, 514171000

This invention relates to the treatment and/or prevention of depression and/or anxiety disorders and/or dementia by the administration of an estrogen receptor beta (ERβ) selective agonist either as a single agent, or in combination with other agents.

20090137529, May 28, 2009

May 11, 2007

12/226934

William K. Hagmann - Westfield NJ, US
Milton L. Hammond - Somerville NJ, US

A61K 31/675
C07D 211/72
A61K 31/44
C07F 9/06

514 89, 546300, 514351, 546 24

The compounds of the present invention are prodrugs of modulators of the Cannabinoid-1 (CB 1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB 1) receptor. In particular, compounds of the present invention are 5 prodrugs of antagonists or inverse agonists of the CB 1 receptor. The invention is concerned with the use of these compounds to be converted to compounds that modulate the Cannabinoid-1 (CB 1) receptor. As such, the compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-10 Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia.

62880543, Sep 11, 2001

May 24, 1999

9/317777

Frank P. Dininno - Old Bridge NJ
Milton L. Hammond - Somerville NJ
Kevin D. Dykstra - West Milford NJ

Merck & Co., Inc. - Rahway NJ

C07D47714
C07D51906
A61K 31428
A61P 3104
C07F 718

51421009

The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.

55654452, Oct 15, 1996

Feb 22, 1995

8/391857

Lovji D. Cama - Teaneck NJ
Milton L. Hammond - Somerville NJ
Mary F. Sasor - East Windsor NJ

Merck & Co., Inc. - Rahway NJ

A61K 31395
C07D46300

514210

1-Carba-1-dethiacephalosporin compounds of the formula I ##STR1## are disclosed. The compounds are useful against MRSA/MRCNS. Compositions and methods of use are also included.