Inventors:
Michelle Arkin - San Francisco CA, US
Robert McDowell - San Francisco CA, US
Johan Oslob - Sunnyvale CA, US
Brian Raimundo - San Francisco CA, US
Nathan Waal - San Francisco CA, US
Chul Yu - San Francisco CA, US
International Classification:
A61K031/506
A61K031/496
A61K031/454
A61K031/4439
A61K031/427
A61K031/422
A61K031/4178
A61K031/4184
C 07D 4 3/02
C 07D 4 3/14
US Classification:
514/254050, 514/326000, 544/371000, 546/211000, 514/256000, 514/341000, 514/397000, 514/394000, 514/365000, 514/374000, 544/331000, 548/191000, 548/222000, 548/305400, 548/312400
Abstract:
Compounds of formulae I and I′, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.