Michael K Wong

D562718, Feb 26, 2008

May 1, 2007

29/286290

Michael Wong - New York NY, US

1101

D11 40

8609635, Dec 17, 2013

Mar 4, 2011

13/041082

Anilkumar Gopinadhan Nair - Edison NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Seong Heon Kim - Livingston NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Stuart Rosenblum - West Orange NJ, US
Oleg B. Selyutin - West Windsor NJ, US
Michael Wong - Somerset NJ, US
Wensheng Yu - Edison NJ, US
Qingbei Zeng - Edison NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

A61K 31/695
C07F 7/10

514 63, 544 60, 544 69, 546 14, 548110

The present invention relates to novel Fused Tricyclic Silyl Compounds of Formula (I):.

20060205797, Sep 14, 2006

Jul 13, 2005

11/180863

Wensheng Yu - Edison NJ, US
Ling Tong - Warren NJ, US
Lei Chen - Roselle Park NJ, US
Joseph Kozlowski - Princeton NJ, US
Brian Lavey - New Providence NJ, US
Neng-Yang Shih - Warren NJ, US
Vincent Madison - Mountain Lakes NJ, US
Guowei Zhou - Livingston NJ, US
Peter Orth - New York NY, US
Zhuyan Guo - Scotch Plains NJ, US
Michael Wong - North Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Seong Kim - Livingston NJ, US
Bandarpalle Shankar - Branchburg NJ, US

A61K 31/425
A61K 31/4178
C07D 417/02
C07D 403/02

514373000, 514389000, 548311100, 548213000

This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—combinations thereof.

20060276448, Dec 7, 2006

Feb 14, 2006

11/353474

Qingbei Zeng - Edison NJ, US
De-Yi Yang - Morris Plains NJ, US
Stuart Rosenblum - West Orange NJ, US
Michael Wong - North Brunswick NJ, US
Gopinadhan Anilkumar - Edison NJ, US
Seong Kim - Livingston NJ, US
Wensheng Yu - Edison NJ, US
Joseph Kozlowski - Princeton NJ, US
Neng-Yang Shih - Warren NJ, US
Brian McGuinness - Plainsboro NJ, US
Doublas Hobbs - Yardley PA, US

A61K 31/5377
A61K 31/506
A61K 31/497
C07D 413/14
C07D 403/14

514210200, 514252110, 544357000, 514235500, 544295000, 544120000

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates or esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

20060276479, Dec 7, 2006

Feb 14, 2006

11/353641

Seong Kim - Livingston NJ, US
Gopinadhan Anilkumar - Edison NJ, US
Michael Wong - North Brunswick NJ, US
Qingbei Zeng - Edison NJ, US
Stuart Rosenblum - West Orange NJ, US
Joseph Kozlowski - Princeton NJ, US
Yuefei Shao - Princeton NJ, US
Brian McGuinness - Plainsboro NJ, US
Douglas Hobbs - Yardley PA, US

A61K 31/497
C07D 413/14
C07D 403/14

514252120, 544357000

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

20060276480, Dec 7, 2006

Feb 14, 2006

11/354328

Michael Wong - North Brunswick NJ, US
Youheng Shu - Blue Bell PA, US
Wensheng Yu - Edison NJ, US
Stuart Rosenblum - West Orange NJ, US
Joseph Kozlowski - Princeton NJ, US
Brian McGuinness - Plainsboro NJ, US
Yuefei Shao - Princeton NJ, US
Douglas Hobbs - Yardley PA, US

A61K 31/496
C07D 403/14

514253010, 544364000

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

20060276506, Dec 7, 2006

Jan 17, 2006

11/333663

Wensheng Yu - Edison NJ, US
Ling Tong - Warren NJ, US
Lei Chen - Roselle Park NJ, US
Joseph Kozlowski - Princeton NJ, US
Brian Lavey - New Providence NJ, US
Neng-Yang Shih - Warren NJ, US
Vincent Madison - Mountain Lakes NJ, US
Guowei Zhou - Livingston NJ, US
Peter Orth - New York NY, US
Zhuyan Guo - Scotch Plains NJ, US
Michael Wong - North Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Seong Kim - Livingston NJ, US
Bandarpalle Shankar - Branchburg NJ, US
M. Siddiqui - Newton MA, US
Kristin Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Umar Mansoor - Framingham MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US

A61K 31/4709
A61K 31/4245
A61K 31/4178
C07D 413/14
C07D 403/02

514314000, 514389000, 546176000, 548311100, 548311400, 514364000, 548126000

This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

20070197564, Aug 23, 2007

Jan 16, 2007

11/653511

Brian Lavey - New Providence NJ, US
Joseph Kozlowski - Princeton NJ, US
Guowei Zhou - Livingston NJ, US
Ling Tong - Warren NJ, US
Wensheng Yu - Edison NJ, US
Michael Wong - North Brunswick NJ, US
Bandarpalle Shankar - Branchburg NJ, US
Neng-Yang Shih - Warren NJ, US
M. Siddiqui - Newton MA, US
Kristin Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US
Razia Rizvi - Bloomfield NJ, US
Lei Chen - Roselle Park NJ, US
De-Yi Yang - Morris Plains NJ, US
Robert Feltz - Parsippany NJ, US
Seong-Heon Kim - Livingston NJ, US

A61K 31/52
C07D 471/02
A61K 31/4745
A61K 31/513
A61K 31/519
C07D 473/02
C07D 487/02

514263200, 514265100, 514303000, 514269000, 514367000, 514300000, 514369000, 544277000, 544310000, 544280000, 546118000, 546119000, 546122000, 548190000

This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.