US Patent:
20180369160, Dec 27, 2018
Inventors:
- Pittsburgh PA, US
- Washington DC, US
Michael Brandt Steketee - Wexford PA, US
Yolandi Van der Merwe - Pittsburgh PA, US
Xinzhu Gu - Jefferson Hills PA, US
Assignee:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION - Pittsburgh PA
DEPARTMENT OF VETERANS AFFAIRS - Washington DC
International Classification:
A61K 9/70
A61K 31/436
A61K 47/34
A61P 25/00
Abstract:
Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.