Search

Michael G Kunitani

from Corte Madera, CA
Age ~75
Get Report
Also known as:
Michael Guy Kunitani, Michael K Kunitani, Michael N Kunitani, Mike G Kunitani
Phone and address:
475 Montecito Ave, Corte Madera, CA 94925
(415) 927-0782
Related to:
Olivia KunitaniJosh NadolDavid Nadol
Connected to:
Bryan C Kunitsky, 45Deanna L Kunitz, 64Jeffrey Kunitz, 51Katherine Kunitz, 37Libra S Kunitz, 47Robert P Kunitz, 83Hiroko T Kuniya, 67Shiina L Kuniyoshi, 36Samkutty Kunjachan, 60Sanjay Kunjachen, 47

Michael Kunitani Phones & Addresses

  • 475 Montecito Ave, Corte Madera, CA 94925 (415) 927-0782 (415) 927-2239
  • Cloverdale, CA
  • Los Angeles, CA
  • Clearlake, CA
  • San Rafael, CA
  • Oakland, CA
  • San Leandro, CA
  • Sonoma, CA
  • Lake La, CA
  • 475 Montecito Ave, Corte Madera, CA 94925

Education

Degree: Graduate or professional degree

Business Records

Name / Title
Company / Classification
Phones & Addresses
Michael Kunitani
Omina, LLC
Real Estate Investment · Nonclassifiable Establishments
475 Montecito Ave, Corte Madera, CA 94925

Publications

Us Patents

Analysis And Separation Of Platelet-Derived Growth Factor Proteins

View page
US Patent:
6448382, Sep 10, 2002
Filed:
Apr 14, 2000
Appl. No.:
09/549290
Inventors:
Michael Kunitani - Corte Madera CA
An D. Tran - Moraga CA
Hugh Parker - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C07K 1449
US Classification:
530416, 530399, 530412, 435 695, 43525421, 435183, 4241851
Abstract:
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

Analysis And Separation Of Platelet-Derived Growth Factor Proteins

View page
US Patent:
7084262, Aug 1, 2006
Filed:
Jul 26, 2002
Appl. No.:
10/205693
Inventors:
Michael Kunitani - Corte Madera CA, US
An D. Tran - Moraga CA, US
Hugh Parker - Oakland CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C07K 14/49
A61K 38/18
US Classification:
530412, 530416, 530399, 435 691, 43525421
Abstract:
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

Analysis And Separation Of Platelet-Derived Growth Factor Proteins

View page
US Patent:
20060252695, Nov 9, 2006
Filed:
Jul 7, 2006
Appl. No.:
11/483033
Inventors:
Michael Kunitani - Corte Madera CA, US
An Tran - Moraga CA, US
Hugh Parker - Oakland CA, US
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
A61K 38/18
C12P 21/06
C12N 1/18
C07K 14/49
US Classification:
514012000, 530399000, 435069100, 435254210
Abstract:
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

Therapeutic Uses Of Resolved Intact Or Clipped Native-Sequence Pdgf-Bb Dimers

View page
US Patent:
60839104, Jul 4, 2000
Filed:
Dec 12, 1997
Appl. No.:
8/989250
Inventors:
Michael Kunitani - Corte Madera CA
An D. Tran - Moraga CA
Hugh Parker - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
A61K 3818
US Classification:
514 8
Abstract:
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

Process For Recovering Microbially Produced Interleukin-2 And Purified Recombinant Interleukin-2 Compositions

View page
US Patent:
45697906, Feb 11, 1986
Filed:
Mar 28, 1984
Appl. No.:
6/594223
Inventors:
Kirston Koths - Berkeley CA
James Thomson - Albany CA
Michael Kunitani - Oakland CA
Kenneth Wilson - Walnut Creek CA
Wolf Hanisch - Oakland CA
Assignee:
Cetus Corporation - Emeryville CA
International Classification:
C07K 312
C12D 2102
US Classification:
260112R
Abstract:
A process for recovering microbially produced IL-2 in a highly pure form from the cellular material of the microorganisms that produced it comprising: disrupting the cell membranes of the microorganisms; extracting the disruptate with a chaotropic agent, such as urea, that selectively extracts microbial proteins from the cellular material; solubilizing the IL-2 in the solid phase of the extraction mixture with an aqueous solution of a solubilizing agent, such as SDS, containing a reducing agent; and separating the IL-2 from the resulting solution by an optional extraction with 2-butanol or 2-methyl-2-butanol followed by gel filtration chromatography, oxidizing the IL-2 and purifying the oxidized IL-2 by RP-HPLC.

Hplc Light Scattering Detector For Biopolymers

View page
US Patent:
52699374, Dec 14, 1993
Filed:
Oct 23, 1990
Appl. No.:
7/601840
Inventors:
Gavin D. Dollinger - San Francisco CA
Robert L. Cunico - Hercules CA
Michael G. Kunitani - San Rafael CA
Assignee:
Cetus Corporation - Emeryville CA
International Classification:
B01D 1508
US Classification:
210656
Abstract:
A high angle light scattering detector using classical Rayleigh scattering. A high intensity arc light source, filtered to leave only one wavelength illuminates a flow cell. Through the flow cell, very small particles such as biological proteins flow in solution after separation by HPLC or some other means. A UV detector generates data regarding the weight concentration of the eluting particles and a scattered light detector collecting scattered light at angles of approximately 90. degree. generates a scattered light signal. The incident light intensity is also measured. The average molecular weight is then computed using the scattered and incident light data the weight concentration data and a simplified mathematical relationship from which the size factor P and the viral coefficients have been eliminated.

Hplc Light Scattering Detector For Biopolymers

View page
US Patent:
52501868, Oct 5, 1993
Filed:
Oct 9, 1992
Appl. No.:
7/959112
Inventors:
Gavin D. Dollinger - San Francisco CA
Robert L. Cunico - Hercules CA
Michael G. Kunitani - San Rafael CA
Assignee:
Cetus Corporation - Emeryville CA
International Classification:
B01D 1508
US Classification:
210656
Abstract:
A high angle light scattering detector using classical Rayleigh scattering. A high intensity arc light source, filtered to leave only one wavelength illuminates a flow cell. Through the flow cell, very small particles such as biological proteins flow in solution after separation by HPLC or some other means. A UV detector generates data regarding the weight concentration of the eluting particles and a scattered light detector collecting scattered light at angles of approximately 90. degree. generates a scattered light signal. The incident light intensity is also measured. The average molecular weight is then computed using the scattered and incident light data, the weight concentration data and a simplified mathematical relationship from which the size factor P and the viral coefficients have been eliminated.

Purified, Reduced Recombinant Interleukin-2 Compositions

View page
US Patent:
54198992, May 30, 1995
Filed:
May 6, 1992
Appl. No.:
7/879753
Inventors:
Kirston Koths - Berkeley CA
James Thomson - Albany CA
Michael Kunitani - Oakland CA
Kenneth Wilson - Walnut Creek CA
Wolf Hanisch - Oakland CA
International Classification:
C07K 1455
A61K 3820
US Classification:
424 852
Abstract:
A process for recovering microbially produced IL-2 in a highly pure form from the cellular material of the microorganisms that produced it comprising: disrupting the cell membranes of the microorganisms; extracting the disruptate with a chaotropic agent, such as urea, that selectively extracts microbial proteins from the cellular material; solubilizing the IL-2 in the solid phase of the extraction, mixture with an aqueous solution of a solubilizing agent, such as SDS, containing a reducing agent; and separating the IL-2 from the resulting solution by an optional extraction with 2-butanol or 2-methyl-2-butanol followed by gel filtration chromatography, oxidizing the IL-2 and purifying the oxidized IL-2 by RP-HPLC.
Control profile
Michael G Kunitani from Corte Madera, CA, age ~75 Get Report