Michael W Cross

7375321, May 20, 2008

May 7, 2003

10/502551

Michael L. Roukes - Pasadena CA, US
Scott E. Fraser - La Canada CA, US
Jerry E. Solomon - Glendale CA, US
Jessica L. Arlett - Altadena CA, US
Michael C. Cross - Claremont CA, US

California Institute of Technology - Pasadena CA

G01N 13/16

250306, 250307, 250309, 702 19, 257414

A bioNEMS device comprises a piezoresistive cantilever having flexing legs of which attach the cantilever to a support and a biofunctionalized portion at the tip. A bias current applied to the legs is limited by a maximal acceptable temperature increase at the biofunctionalized tip. The length of the cantilever has a magnitude chosen to minimize background Johnson noise. A catalyzed receptor on the device binds to a ligand whose binding rate coefficient is enhanced. The catalyst lowers the receptor-ligand binding activation energy and is designed by forced evolution to preferentially bind with the ligand. A carrier signal is injected by a magnetic film disposed on the cantilever which is electromagnetically coupled to a source of the carrier signal. A plurality of NEMS fluidicly coupled transducers generate a plurality of output signals from which a collective output signal is derived, either by averaging or thresholding. The NEMS devices are disposed in microfluidic flow channels and fabricated in a membrane.

7407814, Aug 5, 2008

Aug 9, 2001

09/927779

Michael L. Roukes - Pasadena CA, US
Scott E. Fraser - LaCanada CA, US
Jerry E. Solomon - Glendale CA, US
Michael C. Cross - Claremont CA, US

California Institute of Technology - Pasadena CA

G01N 33/543

436518

A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.

7989198, Aug 2, 2011

Jun 27, 2008

12/216062

Michael L. Roukes - Pasadena CA, US
Scott E. Fraser - LaCanada CA, US
Jerry E. Solomon - Glendale CA, US
Michael C. Cross - Claremont CA, US

California Institute of Technology - Pasadena CA

C12M 3/00

4352872

A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.

8329452, Dec 11, 2012

Jul 14, 2011

13/183336

Michael L. Roukes - Pasadena CA, US
Scott E. Fraser - LaCanada CA, US
Jerry E. Solomon - Glendale CA, US
Michael C. Cross - Claremont CA, US

California Institute of Technology - Pasadena CA

C12M 1/34

4352872

A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device according to the invention generally comprises a nanomechanical mechanical resonator, a detector integral with the mechanical resonator for measuring the mechanical displacement of the resonator, and electronics connected to the detector for communicating the results to a user. A system of biofunctionalized nanoelectromechanical devices and a method for utilizing the biofunctionalized nanoelectromechanical device of the present invention are also provided.

8378758, Feb 19, 2013

Apr 27, 2011

13/095692

Luis Guillermo Villanueva Torrijo - Los Angeles CA, US
Rassul Karabalin - Pomona CA, US
Matthew Matheny - Diamond Bar CA, US
Philip X.-L. Feng - Beachwood OH, US
Michael C. Cross - Claremont CA, US
Michael L. Roukes - Pasadena CA, US

California Institute of Technology - Pasadena CA

H03B 5/36

331156, 331154, 331116 R

A parametric feedback oscillator includes a resonator which has at least one transduction element and at least one electromechanical resonating element. The resonator is configured to accept as input a parametric excitation signal at a frequency and to provide a resonating output signal at a frequency ω. A cascaded feedback path in any electrically coupled cascade order includes at least one non-linear element, at least one phase shifter electrically, and at least one amplifier. The cascade feedback path is configured to receive as input the resonating output signal at a frequency ωand configured to provide as output a feedback path signal as the parametric excitation signal at a frequency to the resonator. A parametric feedback oscillator output terminal is configured to provide the resonating output signal at the frequency ωas an output signal. A method of causing a parametric feedback oscillation is also described.

20220215316, Jul 7, 2022

Jan 3, 2022

17/567871

- Edina MN, US
Mark Edward TASSEEL - Bishop's Stortford, GB
Vlado SKOKO - Belgrade, RS
Michael Harold CROSS - Rancho Palos Verdes CA, US

G06Q 10/06
G06Q 30/06
G06Q 30/02
G06F 9/451

Embodiments of the present disclosure provide systems and methods for generating a microsite and monitoring customer experience thereof. The method performed by a server system includes receiving a service request for accessing microsite services. The method includes rendering a wizard suite associated with the microsite services for enabling a user to create the microsite of a source webpage. Further, the method includes receiving one or more microsite parameters associated with the wizard suite based on user inputs in the wizard suite. The microsite parameters include a microsite type and a microsite template including a plurality of dynamic microsite elements. The method further includes receiving content data of the source webpage to be populated in corresponding dynamic microsite element of the microsite template. The method includes generating the microsite of the source webpage based at least on a combination of the one or more micro site parameters and the content data.

20140176203, Jun 26, 2014

Oct 25, 2013

14/063905

- Pasadena CA, US
Michael L. Roukes - Pasadena CA, US
Michael C. Cross - Arroyo Grande CA, US
Luis Guillermo Villanueva Torrijo - Los Angeles CA, US
Rassul Karabalin - Los Angeles CA, US

California Institute of Technology - Pasadena CA

H03L 7/00

327146

Synchronization of oscillators based on anharmonic nanoelectromechanical resonators. Experimental implimentation allows for unprecedented observation and control of parameters governing the dynamics of synchronization. Close quantitative agreement is found between experimental data and theory describing reactively coupled Duffing resonators with fully saturated feedback gain. In the synchonized state, a significant reduction in the phase noise of the oscillators is demonstrated, which is key for applications such as sensors and clocks. Oscillator networks constructed from nanomechanical resonators form an important laboratory to commercialize and study synchronization—given their high-quality factors, small footprint, and ease of co-integration with modern electronic signal processing technologies. Networks can be made including one-, two-, and three-dimensional networks. Triangular and square lattices can be made.