Mei Chuan Wu

58436359, Dec 1, 1998

Feb 27, 1995

8/395149

Stuart F. Schlossman - Newton MA
Mei X. Wu - Cambridge MA

Dana-Farber Cancer Institute, Inc. - Boston MA

C12Q 170
G01N 33564
C07K 1600

435 5

Methods for interfering with antigen presenting cell-mediated priming of resting peripheral blood T lymphocytes to undergo activation induced cell death ("apoptosis") by inhibiting an interaction between a membrane associated molecule ("an APC apoptotic ligand") present on stimulated antigen presenting cells ("APC") and a counter-receptor that is present on T lymphocytes are disclosed. The antigen presenting cells are preferably from the monocyte/macrophage cell line or are dendritic cells. Also disclosed are methods of screening for inhibitors of APC-mediated priming of T lymphocytes to undergo apoptosis and methods and agents for detecting, identifying and characterizing an APC apoptotic ligand. Inhibitors identified by the screening method of the invention are used to reduce the T lymphocyte depletion associated with HIV infection and thereby mitigate the severe immunodeficiency associated with AIDS by interfering with the association between HIV-infected antigen presenting cells, especially monocytes and macrophages, and T cells.

20230080345, Mar 16, 2023

Mar 5, 2021

17/909287

- Boston MA, US
Mei X. Wu - Boston MA, US

A61N 5/06

Low level light (LLL) can be used to restore a subject's gut microbiota to a state of health. The LLL can be applied directly to the subject's abdomen and/or back, or the LLL can be applied to a feces sample obtained from the subject, which is subsequently administered back to the subject. The subject may be suffering from guy dysbiosis resulting from a variety of different types of bodily stress, such as chemotherapy or radiation therapy.

20180008838, Jan 11, 2018

Jan 22, 2016

15/545039

- Boston MA, US
Mei X. Wu - Boston MA, US

A61N 5/06
A61B 5/00
A61B 5/145
A61M 37/00
A61B 5/15
A61N 5/067

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject.