Mary Anne Neville

20020051813, May 2, 2002

Jun 1, 2001

09/870691

Lawrence Boni - Monmouth Junction NJ, US
Michael Batenjany - Hamilton NJ, US
Richard Robb - Princeton Junction NJ, US
Mircea Popescu - Plansboro NJ, US
Mary Neville - Jamesburg NJ, US

A61K009/127
A61K038/19
A61K038/20
A61K031/739

424/450000, 424/085100, 424/085200, 514/054000

The invention describes a Lipomatrix composed of lipid lattices of stacked bilayers which, when hydrated, form liposomes. The invention also provides a simplified method used to generate highly effective liposomal preparations. Vaccine compositions having superior immunological properties use biomedical-grade liposomes which can be produced from a Lipomatrix, using safe and efficient methods. Use of the inventive methods produces highly potent vaccines against tumor antigens.

56587449, Aug 19, 1997

Jul 22, 1994

8/277299

Augusto C. Ochoa - Frederick MD
Howard A. Young - Gaithersburg MD
Dan L. Longo - Kensington MD
Paritosh Ghosh - Frederick MD
Richard Robb - Princeton Junction NJ
Mary Neville - Jamesburg NJ

The United States of America as represented by the Department of Health
and Human Services - Washington DC
Biomira USA Inc. - Cranbury NJ

C12Q 168
G01N 3368

435 724

Methods of identifying a patient having an altered immune status involve determining an immune status index for the patient and comparing it to the immune status index in healthy individuals. In general, an immune status index is the ratio of the amount of a protein that varies significantly in a patient with an altered immune status to the amount of another protein that is substantially invariant in both healthy and immune-altered individuals. Variable proteins can be TCR subunit proteins, T lymphocyte signal transduction pathway proteins, polynucleotide binding proteins or biological response modifiers (BRM). In addition, the ratio of a TH-1-type BRM to a TH-2-type BRM, the ratio of cytoplasmic to nuclear levels of polynucleotide binding proteins, the pattern of protein binding to an oligonucleotide probe that comprises the protein binding region of a gene for a BRM, or the pattern of distribution of T lymphocytes in a density gradient following density gradient centrifugation are also suitable as an immune status index. The methods are useful in identifying patients exhibiting immunosuppression, hyperimmunity and autoimmunity, as well as in assessing the immune status of a patient undergoing organ transplant.