US Patent:
20020174446, Nov 21, 2002
Inventors:
Dalia Cohen - Livingston NJ, US
Uwe Dengler - Loerrach, DE
Alyce Finelli - Parsippany NJ, US
Felix Freuler - Riehen, CH
Mary Konsolaki - Westfield NJ, US
Mischa Reinhardt - Bantzenheim, FR
Susan Zusman - Sudbury MA, US
International Classification:
A01K067/033
A61K031/00
Abstract:
Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.