Mary Jane Wells, Mary J Wells, Maryjane K Garry, Mary J Garry, Maryjane K Wells, Maryjane Kim Garry, Mary Wells Jane, Samuel Mary Jane, Garry Maryjanek
Mary Garry - Dallas TX, US Ilya Bezprozvanny - Dallas TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C07H 21/00 C40B 40/06
US Classification:
536 235, 506 16, 506 17, 536 234
Abstract:
The present invention relates to peptides of CaV2. 2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2. 2. and is believed to inhibit the interaction of CaV2. 2 with Mint1-PDZ1. The invention is related to use of this peptide to treat pain and to use of this peptide in binding reaction with int-PDZ to screen for small molecules that can inhibit pain.
The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the interaction of CaV2.2 with Mint1-PDZ1. The invention is related to use of this peptide to treat pain and to use of this peptide in binding reaction with int-PDZ to screen for small molecules that can inhibit pain.