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Mary E Ballestas

from Atlanta, GA
Age ~64

Mary Ballestas Phones & Addresses

  • 3650 Ashford Dunwoody Rd NE UNIT 218, Atlanta, GA 30319 (205) 951-8942
  • New Orleans, LA
  • 4916 Maryland Ave, Irondale, AL 35210 (205) 951-8942
  • Birmingham, AL
  • 37 Railroad Ave, Beverly, MA 01915 (978) 921-0064
  • 3701 Academy Dr, Metairie, LA 70003
  • Suffolk, VA
  • 37 Railroad Ave APT 5, Beverly, MA 01915 (978) 857-9127

Work

Position: Service Occupations

Professional Records

Medicine Doctors

Mary Ballestas Photo 1

Mary Ballestas

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Specialties:
Pediatric Infectious Diseases
Work:
Childrens Hospital Of Alabama Pediatric Infectious Diseases
1600 6 Ave S STE 308, Birmingham, AL 35233
(205) 934-2441 (phone), (205) 975-6549 (fax)
Languages:
English
Spanish
Description:
Dr. Ballestas works in Birmingham, AL and specializes in Pediatric Infectious Diseases. Dr. Ballestas is affiliated with Childrens Of Alabama and UAB Highlands Hospital.

Publications

Us Patents

Assays For Compounds That Modulate Rhadino Virus Lana Action In Trans On A Unit Of Rhadino Virus Dna To Mediate Efficient Episome Persistence

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US Patent:
6756203, Jun 29, 2004
Filed:
Jun 28, 2001
Appl. No.:
09/894273
Inventors:
Elliott D. Kieff - Brookline MA, 02445
Mary E. Ballestas - Beverly MA
Kenneth M. Kaye - Weston MA
Assignee:
Elliott D. Kieff - Brookline MA
International Classification:
C12Q 168
US Classification:
435 6, 435 691, 435975, 536 2372
Abstract:
Primary effusion lymphoma (PEL) cells harbor Kaposis sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA co-localized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA co-localized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. The KSHV DNA segment that provides for efficient persistence in LANA positive cells has been identified as the rhodino virus cis-acting element (RVCAE). These results support a model in which LANA tethers episomes containing the KSHV RVCAE DNA to chromosomes during mitosis to enable efficient segregation to progeny cells. The products and methods of the invention are useful in identifying compounds for modulating (especially including interfering with) the persistance of rhodino virus DNA in mammalian cells, and disease states associated therewith, as well as such compounds themselves.

Rhadino Virus Lana Acts In Trans On A Unit Of Rhadino Virus Dna To Mediate Efficient Episome Persistance

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US Patent:
63227924, Nov 27, 2001
Filed:
Apr 21, 1999
Appl. No.:
9/298568
Inventors:
Elliott D. Kieff - Brookline MA
Mary E. Ballestas - Beverly MA
Kenneth M. Kaye - Weston MA
International Classification:
A61K 3912
A61K 39245
C17N 1500
US Classification:
4241991
Abstract:
Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA co-localized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA co-localized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. The KSHV DNA segment that provides for efficient persistence in LANA positive cells has been identified as the rhodino virus cis-acting element (RVCAE). These results support a model in which LANA tethers episomes containing the KSHV RVCAE DNA to chromosomes during mitosis to enable efficient segregation to progeny cells. The products and methods of the invention are useful in identifying compounds for modulating (especially including interfering with) the persistance of rhodino virus DNA in mammalian cells, and disease states associated therewith, as well as such compounds themselves.
Mary E Ballestas from Atlanta, GA, age ~64 Get Report