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Marvin P Wickens

from Madison, WI
Age ~74

Marvin Wickens Phones & Addresses

  • 2804 Columbia Rd, Madison, WI 53705 (608) 238-5356
  • Terrytown, LA
  • Phoenix, AZ
  • 2804 Columbia Rd, Madison, WI 53705 (608) 770-3399

Work

Position: Educator

Education

Degree: Graduate or professional degree

Emails

Resumes

Resumes

Marvin Wickens Photo 1

Professor

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Location:
Madison, WI
Industry:
Higher Education
Work:
University of Wisconsin-Madison
Professor
Education:
Stanford University
Marvin Wickens Photo 2

Marvin Wickens

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Publications

Us Patents

Regulatory Poly(A) Polymerase And Uses Thereof

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US Patent:
20040235001, Nov 25, 2004
Filed:
Sep 18, 2003
Appl. No.:
10/665797
Inventors:
Liaoteng Wang - Madison WI, US
Marvin Wickens - Madison WI, US
Judith Kimble - Madison WI, US
International Classification:
C12Q001/68
C07H021/04
C12P019/34
C12N009/22
US Classification:
435/006000, 435/069100, 435/091200, 435/199000, 435/320100, 435/325000, 536/023200
Abstract:
An isolated preparation of a regulatory poly(A) polymerase (PAP), wherein the polymerase comprises both a catalytic subunit and an RNA-binding subunit is disclosed.

Rna Monomers Containing O-Acetal Levulinyl Ester Groups And Their Use In Rna Microarrays

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US Patent:
20120178638, Jul 12, 2012
Filed:
Sep 4, 2009
Appl. No.:
13/061022
Inventors:
Masad Damha - St-Hubert, CA
Jeremy Lackey - San Jose CA, US
Debbie Mitra - Ottawa, CA
Marvin Wickens - Madison WI, US
Franco Cerrina - Madison WI, US
Saima A. Akhtar - Niskayuna NY, US
Mark Somoza - Weidling, AT
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION - Madison WI
International Classification:
C40B 30/04
C07H 21/02
C40B 40/06
C07H 19/10
C07H 19/20
US Classification:
506 9, 536 268, 536 267, 506 16, 536 243
Abstract:
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.

Tethered Function Assay For Protein Function

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US Patent:
59855754, Nov 16, 1999
Filed:
May 20, 1998
Appl. No.:
9/081731
Inventors:
Marvin P. Wickens - Madison WI
Roy Parker - Tucson AZ
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
The Arizona Board of Regents on behalf of the University of Arizona - Tucson AR
International Classification:
C12Q 168
C07K 1600
C07H 2104
US Classification:
435 6
Abstract:
A method for determining the function of a test protein is disclosed. In a preferred embodiment, this method comprises the steps of fusing a test protein to an RNA-binding protein and exposing the fusion protein to recombinant reporter mRNA molecule that comprises a binding site for the RNA-binding protein in the 3' untranslated region. One then observes the properties of reporter mRNA and correlates the reporter properties with test protein function.

Tethered Function Assay For Protein Function

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US Patent:
63033119, Oct 16, 2001
Filed:
Jul 27, 1999
Appl. No.:
9/361727
Inventors:
Marvin P. Wickens - Madison WI
Roy Parker - Tucson AZ
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
Arizona Board of Regents on behalf of the University of Arizona - Tucson AZ
International Classification:
C12Q 168
C07K 100
US Classification:
435 6
Abstract:
A method for determining the function of a test protein is disclosed. In a preferred embodiment, this method comprises the steps of fusing a test protein to an RNA-binding protein and exposing the fusion protein to recombinant reporter mRNA molecule that comprises a binding site for the RNA-binding protein in the 3' untranslated region. One then observes the properties of reporter mRNA and correlates the reporter properties with test protein function.

System To Detect Protein-Rna Interactions

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US Patent:
57506671, May 12, 1998
Filed:
Nov 12, 1996
Appl. No.:
8/747183
Inventors:
Marvin P. Wickens - Madison WI
Stanley Fields - Setauket NY
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07H 2102
C12Q 168
US Classification:
536 231
Abstract:
A method for detecting an interaction between an RNA-binding protein and a test RNA molecule is disclosed. This method comprises providing a host cell containing a detectable gene. The detectable gene expresses a detectable protein when the detectable gene is activated by an amino acid sequence including a transcriptional activation domain when the transcriptional activation domain is in sufficient proximity to the detectable gene. First, second and third chimeric genes are also provided. The first chimeric gene comprises a DNA-binding domain that recognizes a binding site on the detectable gene in the host cell and a first RNA-binding domain. The second chimeric gene comprises a transcriptional activation domain and a second RNA-binding domain. The third chimeric gene comprises a first RNA sequence capable of binding to either the first or second RNA-binding and a second RNA sequence to be tested for interaction with the RNA-binding protein not bound to the first RNA sequence. Interaction between both the first RNA-binding domain and the hybrid RNA and the second RNA-binding domain and the hybrid RNA in the host cell causes expression of the detectable gene.

System To Detect Protein-Rna Interactions

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US Patent:
56100159, Mar 11, 1997
Filed:
Mar 23, 1995
Appl. No.:
8/409561
Inventors:
Marvin P. Wickens - Madison WI
Stanley Fields - Setauker NY
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
State University of New York at Stony Brook - Stony Brook NY
International Classification:
C12Q 168
C12Q 102
C07H 2102
US Classification:
435 6
Abstract:
A method for detecting an interaction between an RNA-binding protein and a test RNA molecule is disclosed. This method comprises providing a host cell containing a detectable gene. The detectable gene expresses a detectable protein when the detectable gene is activated by an amino acid sequence including a transcriptional activation domain when the transcriptional activation domain is in sufficient proximity to the detectable gene. First, second and third chimeric genes are also provided. The first chimeric gene comprises a DNA-binding domain that recognizes a binding site on the detectable gene in the host cell and a first RNA-binding domain. The second chimeric gene comprises a transcriptional activation domain and a second RNA-binding domain. The third chimeric gene comprises a first RNA sequence capable of binding to either the first or second RNA-binding and a second RNA sequence to be tested for interaction with the RNA-binding protein not bound to the first RNA sequence. Interaction between both the first RNA-binding domain and the hybrid RNA and the second RNA-binding domain and the hybrid RNA in the host cell causes expression of the detectable gene.

Prosthetic Rna And Use Thereof To Modify Rna Expression

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US Patent:
57260591, Mar 10, 1998
Filed:
Jun 6, 1995
Appl. No.:
8/467038
Inventors:
Marvin P. Wickens - Madison WI
Michael D. Sheets - Berkeley CA
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12N 500
C12N 502
C12N 1500
C07H 2102
US Classification:
435375
Abstract:
Translation characteristics of an mRNA molecule in a cell can be altered by providing a prosthetic RNA molecule that includes a regulatory sequence element and a sequence element complementary to a portion of the mRNA molecule. Alteration can affect the translation rate, the mRNA stability, or the localization of the mRNA molecule.

System To Detect Protein-Rna Interactions

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US Patent:
56771312, Oct 14, 1997
Filed:
Jul 9, 1996
Appl. No.:
8/677153
Inventors:
Marvin P. Wickens - Madison WI
Stanley Fields - Setauket NY
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 160
C12D 2104
C12N 1500
C07H 2100
US Classification:
435 6
Abstract:
A method for detecting an interaction between an RNA-binding protein and a test RNA molecule is disclosed. This method comprises providing a host cell containing a detectable gene. The detectable gene expresses a detectable protein when the detectable gene is activated by an amino acid sequence including a transcriptional activation domain when the transcriptional activation domain is in sufficient proximity to the detectable gene. First, second and third chimeric genes are also provided. The first chimeric gene comprises a DNA-binding domain that recognizes a binding site on the detectable gene in the host cell and a first RNA-binding domain. The second chimeric gene comprises a transcriptional activation domain and a second RNA-binding domain. The third chimeric gene comprises a first RNA sequence capable of binding to either the first or second RNA-binding and a second RNA sequence to be tested for interaction with the RNA-binding protein not bound to the first RNA sequence. Interaction between both the first RNA-binding domain and the hybrid RNA and the second RNA-binding domain and the hybrid RNA in the host cell causes expression of the detectable gene.
Marvin P Wickens from Madison, WI, age ~74 Get Report