US Patent:
20120178638, Jul 12, 2012
Inventors:
Masad Damha - St-Hubert, CA
Jeremy Lackey - San Jose CA, US
Debbie Mitra - Ottawa, CA
Marvin Wickens - Madison WI, US
Franco Cerrina - Madison WI, US
Saima A. Akhtar - Niskayuna NY, US
Mark Somoza - Weidling, AT
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION - Madison WI
International Classification:
C40B 30/04
C07H 21/02
C40B 40/06
C07H 19/10
C07H 19/20
US Classification:
506 9, 536 268, 536 267, 506 16, 536 243
Abstract:
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.