Martin Kaczocha

20120165388, Jun 28, 2012

Jan 19, 2010

13/145058

Dale Deutsch - Stony Brook NY, US
Martin Kaczocha - Dix Hills NY, US
Sherrye Glaser - Dix Hills NY, US

The Research Foundation of State University of New York - Albany NY

A61K 31/7088
A61P 25/00
A61K 31/713
G01N 33/566

514 44 A, 436501

The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of the endocannabinoid with an intracellular fatty acid binding protein (FABP). The invention also provides a method of identifying an agent for modulating the level of an endo cannabinoid in a subject comprising testing the agent for its ability to modulate binding of the endocannabinoid with an intracellular FABP. The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate expression of an intracellular FABP. The invention also provides a method of identifying an agent for treatment of a neurological disorder comprising testing the agent for its ability to modulate the interaction of an endocannabinoid with an intracellular FABP. The invention also relates to modulation of levels of fatty acid amides for treatment or amelioration of diseases or disorders by modulating binding of the fatty acid amides to fatty acid binding proteins. In one embodiment, the fatty acid binding protein is one or more of FABP3, FABP5, and FABP7. In one embodiment, the level of an endocannabinoid is modulated.

20230017948, Jan 19, 2023

Nov 24, 2020

17/779214

Iwao OJIMA - Port Jefferson NY, US
Martin Martin KACZOCHA - Dix Hills NY, US
Gregory CARBONETTI - Bloomfield NJ, US
- Albany NY, US

The Research Foundation for The State University of New York - Albany NY

A61K 31/216
A61K 31/337
A61K 45/06
A61P 35/00
C07C 69/757

This invention provides a method of treating a subject afflicted with a cancer comprising periodically administering to the subject an amount of a FABP5 inhibitor and an amount of an anticancer therapy, wherein the amounts when taken together are effective to treat the subject. This invention also provides FABP5 inhibitors for use as an add-on therapy or in combination with an anticancer therapy or in treating a subject afflicted with a cancer. This invention also provides the use of a FABP5 inhibitor in the manufacturing of a medicament for use in combination or as an add on with an anticancer therapy in treating a subject afflicted with cancer, wherein the FABP5 inhibitor and the anticancer therapy are administered simultaneously, contemporaneously or concomitantly. This invention also provides a pharmaceutical composition comprising an amount of a FABP5 inhibitor and an amount of an anticancer therapy for use in treating a subject afflicted with a cancer, wherein the FABP5 inhibitor and an anticancer therapy are administered sequentially or simultaneously.

20190201365, Jul 4, 2019

Feb 15, 2019

16/276920

Iwao Ojima - Port Jefferson NY, US
Dale Deutsch - Stony Brook NY, US
Martin Kaczocha - Dix Hills NY, US
William T. Berger - Mastic NY, US
Robert Rizzo - Huntington NY, US
Trent E. Balius - Stony Brook NY, US

The Research Foundation for The State University of New York - Albany NY

A61K 31/216
C07C 69/76
A61K 31/194
G01N 33/68
C07C 67/08
C07C 211/58
C07C 69/757
C07C 69/753
G01N 33/566
C07C 67/48
C07C 235/40
C07C 235/38
C07C 233/58
C07C 233/11

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

20190062261, Feb 28, 2019

Mar 10, 2017

16/080493

- Albany NY, US
Dale Deutsch - Stony Brook NY, US
Martin Kaczocha - Dix Hills NY, US
Kongzhen Hu - Port Jefferson NY, US
Simon Tong - Great Neck NY, US
Matthew Elmes - Stony Brook NY, US
Su Yan - Stony Brook NY, US

The Research Foundation for the State University of New York - Albany NY

C07C 69/753
C07D 249/06
C07D 215/06
C07C 205/55
C07C 69/757

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)

20170216241, Aug 3, 2017

Feb 10, 2017

15/429656

Iwao Ojima - Port Jefferson NY, US
Dale Deutsch - Stony Brook NY, US
Martin Kaczocha - Dix Hills NY, US
William T. Berger - Mastic NY, US
Robert Rizzo - Huntington NY, US
Trent E. Balius - Stony Brook NY, US

The Research Foundation for The State University of New York - Albany NY

A61K 31/216
G01N 33/68
A61K 31/194

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:

20150183715, Jul 2, 2015

Jul 19, 2013

14/413621

Iwao Ojima - Port Jefferson NY, US
Dale Deutsch - Stony Brook NY, US
Martin Kaczocha - Dix Hills NY, US
William T. Berger - Mastic NY, US
Robert Rizzo - Huntington NY, US
Trent E. Balius - Stony Brook NY, US

The Research Foundation for The State University of New York - Albany NY

C07C 69/757
C07C 67/48
G01N 33/566
C07C 67/08

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure: