US Patent:
20190153022, May 23, 2019
Inventors:
- Irving TX, US
Xin JIANG - Coppell TX, US
Martha R. HOTEMA - Hurst TX, US
Chitase LEE - Ann Arbor MI, US
Bradley William CAPRATHE - Livonia MI, US
William H. ROARK - Ann Arbor MI, US
Gary L. BOLTON - Ann Arbor MI, US
International Classification:
C07J 63/00
C07J 71/00
A61P 29/00
Abstract:
Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.