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Marta S Zarandi

from Miami Beach, FL
Age ~80
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Connected to:
Mike J Zarandona, 41Jennifer E Zaranek, 53Audra A Zaranka, 63Charlotte A Zaranka, 78Alla Zarankina, 67Tal Zarankin, 54Maria Zaranski, 58Sandhya E Zarapkar, 81Alice S Zarari, 50Cheri D Zaras, 56

Marta Zarandi Phones & Addresses

  • Miami Beach, FL
  • 6440 Claiborne Ave, New Orleans, LA 70125 (504) 862-9769
  • 6440 S Claiborne Ave #210, New Orleans, LA 70125 (504) 862-9769
  • Somerset, NJ
  • 1099 NW 9Th Ct APT 1, Miami, FL 33136

Publications

Us Patents

Fluorinated Ghrh Antagonists

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US Patent:
8227405, Jul 24, 2012
Filed:
Sep 17, 2009
Appl. No.:
12/562096
Inventors:
Andrew Schally - Miami Beach FL, US
Jozsef Varga - Miami Beach FL, US
Marta Zarandi - Miami Beach FL, US
Ren Zhi Cai - Miami FL, US
Assignee:
University of Miami - Miami FL
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
A61K 38/16
US Classification:
514 11, 424423, 530324
Abstract:
Novel fluorinated synthetic analogs of hGH-RH(1-30)NHthat inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a direct effect on the cancer cells, and to therapeutic compositions containing these novel peptides and their use.

Fluorinated Ghrh Antagonists

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US Patent:
8227421, Jul 24, 2012
Filed:
Sep 17, 2009
Appl. No.:
12/562010
Inventors:
Andrew Schally - Miami Beach FL, US
Jozsef Varga - Miami Beach FL, US
Marta Zarandi - Miami Beach FL, US
Ren Zhi Cai - Miami FL, US
Assignee:
University of Miami - Miami FL
The United States of America represented by the Department of Veteran Affairs - Washington DC
International Classification:
A61K 38/16
C07K 14/65
A61F 2/00
US Classification:
514 213, 514 85, 623 111
Abstract:
Novel fluorinated synthetic analogs of hGH-RH(1-30)NHthat inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a direct effect on the cancer cells, and to therapeutic compositions containing these novel peptides and their use.

Antagonistic Analogs Of Gh Rh (2003)

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US Patent:
20070042950, Feb 22, 2007
Filed:
Jul 26, 2004
Appl. No.:
10/566776
Inventors:
Andrew Schally - Miami FL, US
Jozsef Varga - Metairie LA, US
Marta Zarandi - New Orleans LA, US
Ren Cai - Metairie LA, US
Assignee:
Administrators of the Tulane educational fund, The - New Orleans LA
United States of America represented by The Department of Verterans - Washington DC
International Classification:
A61K 38/16
C07K 14/47
US Classification:
514012000, 530324000
Abstract:
There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

Novel N- And C- Terminal Substituted Antagonistic Analogs Of Gh-Rh

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US Patent:
20130261055, Oct 3, 2013
Filed:
Sep 25, 2010
Appl. No.:
12/890626
Inventors:
Andrew V. Schally - Miami Beach FL, US
Marta Zarandi - Miami Beach FL, US
Jozsef L. Varga - Miami Beach FL, US
Ren Zhi Cai - Miami FL, US
International Classification:
A61K 38/25
A61P 35/00
A61K 38/22
US Classification:
514 81, 530324, 514 112, 514 86, 514 85, 514 91
Abstract:
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH(SEQ ID NO: 96) and hGH-RH(1-30)NH. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH—(CH)—CO-Ada, at the N-Terminus and β-Ala, Amc, Apa, Ada, AEA, AEP, ε-Lys(α-NH), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.

Analogues Of Hgh-Rh(1-29)Nh.sub.2 Having Antagonistic Activity

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US Patent:
55502121, Aug 27, 1996
Filed:
Dec 17, 1993
Appl. No.:
8/168810
Inventors:
Marta Zarandi - Metairie LA
Andrew V. Schally - Metairie LA
Assignee:
The Administrators of the Tulane Educational Fund - New Orleans LA
International Classification:
A61K 3800
C07K 710
C07K 700
US Classification:
530324
Abstract:
Synthetic analogues of hGH-RH(1-29)NH. sub. 2 having substitutions of various amino acids and acylated at the N-terminus, and exhibiting prolonged antagonistic duration. Embodiments include analogues of the formula: ##STR1## wherein X is nil, H, Ac, IAc, BrProp, Ibu, Nac, 2-Nac, 1- or 2-Npt, 1- or 2-Npr or Aqc; R. sup. 1 is Tyr, His, Glu or Glt; R. sup. 2 is D-Arg, D-Cit, D-Har, D-Lys or D-Orn; R. sup. 3 is Asp, Ala or Gly; R. sup. 4 is Ala or Gly; R. sup. 5 is Ile, Ala or Gly; R. sup. 6 is Phe, Ala, Pro, Tpi, Nal or Phe(Y), in which Y is F, Cl, Br, NO. sub. 2, CH. sub. 3 or OCH. sub. 3 ; R. sup. 8 is Asn, Ser, Val, Ile, Ala, Abu, Nle, or Aib; R. sup. 11 is Arg, D-Arg or Cit; R. sup. 12 is Lys, D-Lys, Cit or Ala; R. sup. 15 is Gly, Ala, Abu or Gln; R. sup.
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Marta S Zarandi from Miami Beach, FL, age ~80 Get Report