Inventors:
Yuling Li - Germantown MD
Mark Oelkuct - Frederick MD
Reiner L. Gentz - Rockville MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
A61K 4500
Abstract:
The present invention relates to processes for the purification of proteins. More specifically, methods for solubilizing and purifying proteins expressed in an insoluble form using low concentrations of chaotropic agents, such as guanidine salts, are provided. Also provided are methods for refolding proteins solubilized according to the present invention.