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Mark R Krystal

from Delray Beach, FL
Age ~69
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Also known as:
Mark Raymond Krystal, Mark P Krystal
Related to:
Bryan JensenDaniella M Goldman, 88
Connected to:
Barbara J Krystal, 52Daniel G Krystallis, 49Edith M Krystel, 88Mark Krystinak, 32Karyn M Krystock, 55Heather M Krystofiak, 39Mark A Krystofik, 59Patricia A Krystofek, 72Patricia S Krystofolski, 80Shannon M Krystofek, 42

Mark Krystal Phones & Addresses

  • Delray Beach, FL
  • Leonia, NJ
  • 12 Salem Rd, Westport, CT 06880 (203) 454-1110 (203) 454-4358
  • West Windsor, NJ
  • 1660 150Th St, Miami, FL 33181 (305) 956-5649
  • North Miami, FL
  • Cranbury, NJ
  • Washington, DC
  • Rego Park, NY
  • 12 Salem Rd, Westport, CT 06880

Work

Position: Executive, Administrative, and Managerial Occupations

Education

Degree: Associate degree or higher

Resumes

Resumes

Mark Krystal Photo 1

Director Of Virology At Bristol-Myers Squibb

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Position:
Director of Virology at Bristol-Myers Squibb
Location:
Greater New York City Area
Industry:
Pharmaceuticals
Work:
Bristol-Myers Squibb since Mar 1992
Director of Virology
Mt. Sinai School of Medicine Oct 1980 - Mar 1992
Assistant Professor
Education:
State University of New York at Stony Brook 1976 - 1981
ph.d.

Publications

Us Patents

Substituted Benzimidazole Antiviral Agents

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US Patent:
6908936, Jun 21, 2005
Filed:
Nov 7, 2002
Appl. No.:
10/289829
Inventors:
Kuo-Long Yu - Hamden CT, US
Rita Lee Civiello - Killingworth CT, US
Mark R. Krystal - Westport CT, US
Kathleen F. Kadow - Wallingford CT, US
Nicholas A. Meanwell - East Hampton CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K031/4192
C07D249/18
US Classification:
514359, 548257, 548259, 548260
Abstract:
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.

Substituted Benzimidazole Antiviral Agents

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US Patent:
7030140, Apr 18, 2006
Filed:
Sep 3, 2004
Appl. No.:
10/934921
Inventors:
Kuo-Long Yu - Hamden CT, US
Rita Lee Civiello - Killingworth CT, US
Mark R. Krystal - Westport CT, US
Kathleen F. Kadow - Wallingford CT, US
Nicholas A. Meanwell - East Hampton CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/4192
A61K 31/454
A61K 31/4439
US Classification:
514322, 514338, 514359
Abstract:
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.

Bicyclic Heterocycles As Hiv Integrase Inhibitors

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US Patent:
7157447, Jan 2, 2007
Filed:
Nov 29, 2005
Appl. No.:
11/288533
Inventors:
B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 33/42
C07D 267/14
C07D 279/02
C07D 205/08
C07F 90/542
A61K 31/533
US Classification:
514 80, 540552, 540542, 540362, 540524, 5142111, 5142305, 544105, 544 3
Abstract:
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Bicyclic Heterocycles As Hiv Integrase Inhibitors

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US Patent:
7176196, Feb 13, 2007
Filed:
May 11, 2005
Appl. No.:
11/126891
Inventors:
B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 498/04
C07D 205/08
A61K 31/5365
A61K 31/553
A61K 31/397
A61K 31/675
A61K 31/18
A61P 31/18
US Classification:
5142111, 540552, 540362, 51421002, 5142305, 514 80, 544105
Abstract:
The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Recombinant Negative Strand Rna Virus Expression Systems And Vaccines

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US Patent:
7276356, Oct 2, 2007
Filed:
Nov 28, 2000
Appl. No.:
09/724427
Inventors:
Peter Palese - Leonia NJ, US
Mark Krystal - Westport CT, US
Jeffrey Parvin - Lincoln MA, US
Assignee:
MedImmune Vaccines, Inc. - Mountain View CA
International Classification:
C12P 19/34
C12N 15/63
C12N 15/11
C12N 15/85
C12N 15/86
C07H 15/11
A61K 48/00
US Classification:
435 911, 424 931, 424 912, 4353201, 435325, 435455, 536 231
Abstract:
Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The RNA templates are prepared by transcription of appropriate DNA sequences with a DNA-directed RNA polymerase. The resulting RNA templates are of the negative-polarity and contain appropriate terminal sequences which enable the viral RNA-synthesizing apparatus to recognize the template. Bicistronic mRNAs can be constructed to permit internal initiation of translation of viral sequences and allow for the expression of foreign protein coding sequences from the regular terminal initiation site, or vice versa.

N-[[4-Fluoro-2-(5-Methy-1H-1,2,4-Triazol-1-Yl)Phenyl]Methyl]-4-,6,7,9-Tetrahydro-3-Hydroxy-9,9-Dimethyl-4-Oxo-Pyrimido[2,1-C][1,4]Oxazine-2-Carboxamide As An Hiv Integrase Inhibitor

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US Patent:
7511037, Mar 31, 2009
Filed:
Aug 16, 2006
Appl. No.:
11/505149
Inventors:
B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/5365
A61K 38/16
A61K 35/76
A61K 31/5513
A61K 31/662
A61P 31/18
C07D 498/04
US Classification:
5142305, 514 12, 514220, 514117, 514 81, 544105
Abstract:
The invention encompasses a series of bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Methods Of Treating Hiv Infection

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US Patent:
20060058286, Mar 16, 2006
Filed:
Sep 15, 2005
Appl. No.:
11/227526
Inventors:
Mark Krystal - Westport CT, US
Carol Deminie - Cheshire CT, US
Sagarika Bollini - Hamden CT, US
Brian Terry - Middletown CT, US
International Classification:
A61K 31/551
A61K 31/522
A61K 31/513
A61K 31/195
US Classification:
514220000, 514563000, 514463000, 514263310, 514269000
Abstract:
The invention encompasses pharmaceutical compositions and methods for using Compound 1 or Compound 2 in combination with other agents for treating patients with AIDS or HIV infection.

Recombinant Negative Strand Rna Virus

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US Patent:
55784739, Nov 26, 1996
Filed:
Mar 10, 1994
Appl. No.:
8/209178
Inventors:
Peter Palese - Leonia NJ
Jeffrey D. Parvin - Belmont MA
Mark Krystal - Leonia NJ
Assignee:
Aviron, Inc. - Mountain View CA
International Classification:
C12N 1509
C12N 701
C12N 702
C12N 704
US Classification:
4351723
Abstract:
Recombinant negative strand virus RNA templates which may be used to express heterologous gene products and/or to construct chimeric viruses are described. Influenza viral polymerase, which was prepared depleted of viral RNA, was used to copy small RNA templates prepared from plasmid-encoded sequences. Template constructions containing only the 3' end of genomic RNA were shown to be efficiently copied, indicative that the promoter lay solely within the 15 nucleotide 3' terminus. Sequences not specific for the influenza vital termini were not copied, and, surprisingly, RNAs containing termini identical to those from plus sense cRNA were copied at low levels. The specificity for recognition of the virus-sense promoter was further defined by site-specific mutagenesis. It was also found that increased levels of vital protein were required in order to catalyze both the cap-endonuclease primed and primer-free RNA synthesis from these model templates as well as from genomic length RNAs. This indicated that this reconstituted system had catalytic properties very smilar to those of native viral RNPs.
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Mark R Krystal from Delray Beach, FL, age ~69 Get Report