Inventors:
Olavi Siiman - Davie FL
Alexander Burshteyn - Hialeah FL
Marilyn Cayer - Miami FL
Assignee:
Coulter Corporation - Miami FL
International Classification:
B01J 1322
B32B 1508
B32B 1516
G01N 3352
Abstract:
The invention describes stable colloidal polymeric particles of 0. 2-5. 0 microns size which are coated with a first aminodextran layer and a second metallic solid layer, The metal is coated by reduction of a metallic salt or complex by the aminodextran. The metal coated particles, which preferably are gold- or silver-coated polymeric microspheres, produce side scatter and forward shifts in flow cytometry applications that are in agreement with the theoretical shifts predicted for solid gold or silver spheres of similar size in flow cytometry applications,.